Post on 07-Jul-2018
8/19/2019 Farmacovigilância Abr 2015
1/61
"#$%#&'()*)+,-&)#.!"##$%$&$'(')# ) &$+$,(-.)# '(
+"/$,"0$1(-2" ') 0)(-.)# ('3)0#(#
Maria Helena Seabra Soares de BrittoProfessora Associada DEFAR/UFMA
ABEF
FAIMER 2010
maria.britto@ufma.br
/0$01)-#2 3)#4$)+ 50 6789
8/19/2019 Farmacovigilância Abr 2015
2/61
:)1/;$)&' 0 5010-('+()%0-/'
• 4567 8 469: (;;?@A9 +BCDA9? D9 #9ED< FGH(IJ K
8/19/2019 Farmacovigilância Abr 2015
3/61
4:
8/19/2019 Farmacovigilância Abr 2015
4/61
• 0
8/19/2019 Farmacovigilância Abr 2015
5/61
'
8/19/2019 Farmacovigilância Abr 2015
6/61
$#% < =>#-5' # $0#?@' # >%%05)%0-/' < -'&)(# 0 -@'A
)-/0-&)'-#+ 0 '&'$$0 -#1 5'101-'$%#+%0-/0 >1#5#1 -' :'%0% 3#$#
3$'")+#B)#2 5)#*-;1/)&'2 /0$#3)# 5#
5'0-?# '> 3#$# # %'5)")?@' 50">-?C01 ")1)'+;*)
8/19/2019 Farmacovigilância Abr 2015
7/61
•
R !KR[
8/19/2019 Farmacovigilância Abr 2015
8/61
•
( AD@A9 D< bB< M
8/19/2019 Farmacovigilância Abr 2015
9/61
&'-&0)/'
( m 9 K = 9 M RU A ^ A ? a C M A 9 @ B = M RC [ B C V R D <OKRM
8/19/2019 Farmacovigilância Abr 2015
10/61
"BVKR; OKRDBVR; bB< OKRU9U
8/19/2019 Farmacovigilância Abr 2015
11/61
" R>[
8/19/2019 Farmacovigilância Abr 2015
12/61
:0B)1/0 >1' $#&)'-#+ =>#-5' '1 3#&)0-/01$0&040% %05)%0-/'1 #3$'3$)#5'1 3#$#
1>#1 -0&011)5#501 &+D-) 0% 5'101
#50=>#5#1 E1 1>#1 3#$/)&>+#$)5#501)-5)()5>#)12 3'$ 30$D'5' 50 /0%3'
-0&011F$)' 0 &'% 4#)B' &>1/' 3#$# 0+01 01># &'%>-)5#50G
89:;"? @A:B>?C D9E
8/19/2019 Farmacovigilância Abr 2015
13/61
#QR ;[
8/19/2019 Farmacovigilância Abr 2015
14/61
/9 OKNYM9 D9 m9K=9MRUA^A?aCMA9J ;QR A=ORKV9CV@= 9;
bB
8/19/2019 Farmacovigilância Abr 2015
15/61
)%3'$/,-&)# !9K9 B= CRUR =
8/19/2019 Farmacovigilância Abr 2015
16/61
( ACDE;VKA9 S9K=9M`BYM9 V
8/19/2019 Farmacovigilância Abr 2015
17/61
•
1)-#+ < # )-"'$%#?@' -'/)")# 1'4$03'11D(0+ $0+#?@' >1#+ 0-/$0 >%
0(0-/' #5(0$1' 0 >% %05)%0-/'210-5' =>0 /#+ $0+#?@' < 501&'-:0&)5#'> "') 5'&>%0-/#5# 3$0()#%0-/02 50
"'$%# )-&'%3+0/#G
• -'$%#+%0-/02 %#)1 50 >%# H-)
-'/)")?@' < -0&011F$)# 3#$# *0$#$ >%1)-#+2 5030-50-5' 5# *$#()5#50 5'
0(0-/' 0 5# =>#+)5#50 5# )-"'$%#?@'G
8/19/2019 Farmacovigilância Abr 2015
18/61
u
" CE=
8/19/2019 Farmacovigilância Abr 2015
19/61
:#$%'-)I#?@' < >% /0$%' >/)+)+)I#5' 3'$ >%
3$'J0/' )-/)/>+#5'. K&'-"0$L-&)#)-/0$-#&)'-#+ 1'4$0 :#$%'-)I#?@' 50
0B)*L-&)#1 /%#-'2 =>0 $0H-0 #1#>/'$)5#501 $0*>+#/;$)#1 5# 0>$'3#2 5' J#3@'0 5'1 01/#5'1 >-)5'12 40% &'%' 0130&)#+)1/#1
5# )-5H1/$)# "#$%#&L>/) 5#1 /$L1 $0*)C013#$# 5)1&>/)$ #130&/'1 &)0-/D")&'1 0 //'1:
8/19/2019 Farmacovigilância Abr 2015
20/61
(
8/19/2019 Farmacovigilância Abr 2015
21/61
•
( =RCAVRKAZ9PQR D9 ;
8/19/2019 Farmacovigilância Abr 2015
22/61
•
);VBDR; S9K=9MRK< R; MB;VR; DR; ;
8/19/2019 Farmacovigilância Abr 2015
23/61
3'/0-&)#+ &'%' 5)1&)3+)-# 0 0% 3M5
HN VK`; 9>RKD9^
8/19/2019 Farmacovigilância Abr 2015
24/61
•
( ;
8/19/2019 Farmacovigilância Abr 2015
25/61
e: o9O9MAV9PQRh
•
/9 M9O9MAV9PQR D< OKRL;;ARC9A; D9 ;9ED
8/19/2019 Farmacovigilância Abr 2015
26/61
!RKV9CVRJ 9 =RCAVRKAZ9PQR D9 ;
8/19/2019 Farmacovigilância Abr 2015
27/61
7: (M
8/19/2019 Farmacovigilância Abr 2015
28/61
'
8/19/2019 Farmacovigilância Abr 2015
29/61
"; M
8/19/2019 Farmacovigilância Abr 2015
30/61
$050 4$#1)+0)$# 50 &0-/$'1 50 )-"'$%#?C011'4$0 %05)%0-/'1 N$04$#&)%O2 &$)#5# 3'$
%0)' 5# 3'$/#$)# %)-)1/0$)#+ N%1O -P 6GQRS
50 678T /0% ' '4J0/)(' 50 &''$50-#$ >%#$050 50 &0-/$'1 0 10$()?'1 50 )-"'$%#?C01
1'4$0 %05)%0-/'1 0 &'-1'+)5#$ '3'/0-&)#+ &)0-/D")&' ('+/#5' E 3$'5>?@' 0
5)">1@' 5# )-"'$%#?@' 1'4$0%05)%0-/'1 0 3$'5>/'1 3#$# 1#H50G
8/19/2019 Farmacovigilância Abr 2015
31/61
( ;
8/19/2019 Farmacovigilância Abr 2015
32/61
( ;RMA
8/19/2019 Farmacovigilância Abr 2015
33/61
u
" O
8/19/2019 Farmacovigilância Abr 2015
34/61
• ( 9BVR=
8/19/2019 Farmacovigilância Abr 2015
35/61
( DA;MAO?AC9 D9 S9K=9MRUA^A?aCMA9 D
8/19/2019 Farmacovigilância Abr 2015
36/61
K301=>)1# 0 5010-('+()%0-/'K -'$%#+%0-/0 10$0"0$0 # #/)()5#501 50 +'-*' 3$#I' 0U'> '$)0-/#5#1
#' ">/>$'2 $0+#&)'-#5#1 # &)L-&)# '> /0&-'+'*)#2>1#-5' /0 :#J# $01>+/#5'1 3$% 40-0"D&)' &'%0$&)#+G
=>#+=>0$ 0%3$01# =>0 )-(01/0 %#)1 50 89V 5' 10>'$?#%0-/' 0% 301=>)1# 0 5010-('+()%0-/' N3M5O
*#-:# $03>/#?@' 50 10$ >%# 0%3$01# 50 #+/#/0&-'+'*)#G %>)/#1 0%3$01#1 501/# /0*'$)# 1@' 5'$#%' 50 %05)%0-/'12 &'%' # %0$&W 0 # -'(#$/)1G
8/19/2019 Farmacovigilância Abr 2015
37/61
#XYZ[\] ^\] _`a\] b`cd`ce_`c\] fZa dga`aha[ i\]ed bdeajhc\Xb\`\ 3M5 a[ "\`[\hdicYcXkjhc\2 j\ a]ga`\ j\hcdj\X dZ
cjea`j\hcdj\Xh
4:$D
8/19/2019 Farmacovigilância Abr 2015
38/61
k: oR=BCAM9PQRh
'
8/19/2019 Farmacovigilância Abr 2015
39/61
#3+))+)5#50 3#$# /'5'1 '1 3$'")11)'-#)1
5# 1#H50 • "KA^AC9?=
8/19/2019 Farmacovigilância Abr 2015
40/61
•
"CD< bB
8/19/2019 Farmacovigilância Abr 2015
41/61
•
x R O9MA
8/19/2019 Farmacovigilância Abr 2015
42/61
m9VR A=ORKV9CV< @ R K
8/19/2019 Farmacovigilância Abr 2015
43/61
8/19/2019 Farmacovigilância Abr 2015
44/61
( '
8/19/2019 Farmacovigilância Abr 2015
45/61
• ( ACDE;VKA9 S9K=9M`BYM9 D?AMR < MR= R;
OKRL;;ARC9A; D9 ;9ED
8/19/2019 Farmacovigilância Abr 2015
46/61
)%3#&/' 3'1)/)(' -' 40%A01/#$ 5'1 >1>F$)'1
0 -# 1#H50 &'+0/)(#
( M
8/19/2019 Farmacovigilância Abr 2015
47/61
'] b`cjhlbcd] ^\ ha`mnh\opd j\ cj^q]e`c\ g\`[\hrZmh\ cjhXZa[.
• MB=OKA=
8/19/2019 Farmacovigilância Abr 2015
48/61
• 9K=9Z
8/19/2019 Farmacovigilância Abr 2015
49/61
( =RCAVRKAZ9PQR D9 ;
8/19/2019 Farmacovigilância Abr 2015
50/61
• (?^BC; ^KBOR; OROB?9MARC9A; FMKA9CP9;J ADR;R;J ^
8/19/2019 Farmacovigilância Abr 2015
51/61
u " B;R D< =
8/19/2019 Farmacovigilância Abr 2015
52/61
*`\j^a] ^a]\nd] \ ]a`a[ ajg`aje\^d] baXd] b`dY`\[\] ^a
g\`[\hdicYcXkjhc\28G *Xds\Xct\opd:
" B;R D< =
8/19/2019 Farmacovigilância Abr 2015
53/61
TG #[bXc\opd ^d cjea`a]]a hd[ \ ]aYZ`\jo\"
8/19/2019 Farmacovigilância Abr 2015
54/61
RG 1\q^a bqsXch\ Q)# h`a]hc[ajed ahdjv[chd
^\ cj^q]e`c\ g\`[\hrZmh\G
!RD< ]9U?
8/19/2019 Farmacovigilância Abr 2015
55/61
9G %djced`ct\opd ^a ^aea`[cj\^d] b`d^Zed]:
HN 9 MRCUAMPQR
8/19/2019 Farmacovigilância Abr 2015
56/61
SG #meZ^a] a ba`haboua] fZ\jed \d] sajawhcd] a ^\jd]:
);;9; V
8/19/2019 Farmacovigilância Abr 2015
57/61
xG $a]ZXe\^d] a c[b\hed:
}BCV9=
8/19/2019 Farmacovigilância Abr 2015
58/61
-'/)")?@' •
(; V
8/19/2019 Farmacovigilância Abr 2015
59/61
8/19/2019 Farmacovigilância Abr 2015
60/61
,RDR; R; OKRL;;ARC9A; D< ;9ED< D
8/19/2019 Farmacovigilância Abr 2015
61/61