Apoptose
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Transcript of Apoptose
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Apoptose
UEAESA
PATOLOGIA GERAL
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Apoptose no jardim da Infância
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Apoptose após a lactação
Agora sim !!!No nosso nível ....
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Apoptose em membranas interdigitais Pata de camundongo
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Apoptose – Eventos-chave
Fisiológico/ Patológico
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Caracterização morfológica da apoptose
•Condensação de cromatina•Retração celular•Formação de bolhas citoplasmáticas e corpos apoptóticos•Fagocitose de cels apoptoticos por macrófagos
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Bioquímica da Apoptose
• Ativação das caspases – cisteína proteases– 8 e 9 – iniciadoras– 3 e 6 - executoras
• Quebra de DNA e Proteína – 180 a 200 bp
• Alteraçãoes de Membrana e Reconhecimento pelos fagócitos - fosfatidilserina
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Mecanismo Clássico via Ativação de caspases
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Ativação da apoptose – vias extrínseca e intrínseca
Via Extrínseca
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Receptor – Fas: receptor de morte celular
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Ativação Caspases via FAS similar via TNF
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Ativação da apoptose – via intrínseca
MAC system
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Apoptose Mamíferos
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Fator trófico
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Inibição da apoptose por sinalização através da PI3 - quinase
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Proteínas Pró (bax) e anti (bcl-2)- apoptóticas
Ativação via Interna ou Externa
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GERAL APOPTOSE
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Apoptose em Hepatite Viral
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