Atualidades Hipertrofia

8/12/2019 Atualidades Hipertrofia

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Mtodo

Ten healthy young male subjects (21.8 0.4years, 1.78 0.04 m, 75.6 2.9 kg; mean SE)engaged in unilateral resistance training for 8

week (3 days/week).

Exercises were knee extension and leg pressperformed at 8090% of the subjects singlerepetition maximum (1RM).


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Mtodo

Blood samples were collected in the acuteperiod before and after the Wrst training boutand following the last training bout and analyzedfor total testosterone, free-testosterone,luteinizing hormone, sex hormone bindingglobulin, growth hormone, cortisol, and insulin-like growth factor-1.

Thigh muscle cross sectional area (CSA) andmuscle Wbre CSA by biopsy (vastus lateralis)were measured pre- and post-training.


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Concluso

In conclusion, unilateral training inducedlocal muscle hypertrophy only in theexercised limb, which occurred in the

absence of changes in systemic hormonesthat ostensibly play a role in musclehypertrophy.


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Mtodo

In a single-blind, randomized protocol,resistance-trained males were matched forstrength and placed into one of two groups; thePRE-POST group consumed a supplement (1gIkgj1 body weight) containing protein/creatine/glucose immediately before and after RE.

The MOR-EVE group consumed the same doseof the same supplement in the morning and lateevening.


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Mtodo

All assessments were completed the weekbefore and after 10 wk of structured, supervisedRE training.

Assessments included strength (1RM, threeexercises), body composition (DEXA), andvastus lateralis muscle biopsies for

determination of muscle fiber type (I, IIa, IIx),cross-sectional area (CSA), contractile protein,creatine (Cr), and glycogen content.


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Concluso

Supplement timing represents a simple buteffective strategy that enhances theadaptations desired from RE-training.


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Muscle size and strength are

increased following walk

training with restricted venous

blood flow from the leg.

J.Appl. Physiol. 2006.


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CLULAS SATLITES

Fisiologia e Biologia Molecular


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Msculo Esqueltico

Exibe grande capacidade para se adaptar ademandas fisiolgicas do crescimento,treinamento e leso.

Esse capacidade atribuda a uma pequenapopulao de clulas chamadas de Clu lasSatlites.

Em 1961, Mauro a descobriu e as denominoude Satlites devido a sua localizao nomsculo.


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Localizao das Satlites

Localizam-se na periferia muscular, numespao compreendido entre a laminabasal e o sarcolema.

Diferem completamente da ClulaMuscular, qual situa-se envolvida pelosarcolema (Membrana Plasmtica daFibra Muscular).


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Funo das Clulas Satlites

Em condies fisiolgicas inalteradas,permanecem em estado Quiescente, e nose proliferam.

Em resposta a estmulos como microt rauma,tornam-se ativas, proliferam e expressam

marcadores da Miognese(Mioblastos).

MioblastosRegenerao Muscu lar


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Regenerao Muscular

O processo de regenerao muscularenvolve Fato res de Cresc imen to e umaseqncia de eventos celulares, quais

resultam na regulao da populao dasclulas satlites.

Dentre todos os fatores de crescimentoconhecidos, dois esto bem documentadosna literatura: o IGF-1 e o HGF


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Fator de Crescimento InsulnicoIGF-1

Importante na regulao do metabolismoda Insul ina;

Presentes em processos de regeneraomuscular,

prol i ferandoe

di ferenciandoa

populao de clulas satlites.


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IGF-1, Sobrecarga Muscular eExerccio Excntrico

Muscular [IGF-1] Hipertrof ia

e/ou Hiperplasia.


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Vias de Sinalizao do IGF-1

MAP (Protena Mitognica Ativa) e PI-3K(FosfatidilInositol-3-OH Kinase) so viasque tem sido ativadas na proliferao de

Clulas Satlites.

A Diferenciao parece ser ativada pela

via do PI-3K.


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Processo do Reparo Celular

O aumento da Massa muscular viatreinamento resistido ocorre via Ativao,Pro l i ferao, Migrao e Fuso parafibras musculares existentes.


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Migrao das Clulas satlites

O processo de Migrao das ClulasSatlites depende da integridade daLam ina Basal.

Aps a ruptura da Lamina Basal, as ClulasSatlites usam tecidos adjacentes como

ponte para migrarem ao local da Leso.


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Em resposta ao trauma sem ruptura demembrana, as Clulas Satlites migramsob a Lam ina basal da poro intacta daclula para a parte lesada.

Migrao das Clulas Satlites


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Regenerao


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Toigo & Boutellier, 2006.

Domnio Mio-Nuclear


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Como as CLULAS SATLITESfuncionam ?

[Mioncleos]Trasncrio


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Atualidades Hipertrofia

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