AULA Ciclo Celular
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Transcript of AULA Ciclo Celular
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CICLO CELULAR
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CICLO CELULAR
Ciclo de divisão celular é fundamental para:– Reprodução– Substituir células– Estado de equilíbrio
Aspectos importantes:– DNA fielmente duplicado– Cromossomos segregados em duas células
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Fases do Ciclo Celular:
Interfase: Período G1 Período S Período G2
Mitose: Prófase Pró-metáfase Metáfase Anáfase Telófase
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Divisão Celular é constituída de uma: divisão nuclear: mediada por fuso acromático divisão citoplasmática: mediada pelo anel
contráctil
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Mecanismos que induzem a célula a entrar no Ciclo Celular– força mecânica (distensão do músculo liso) – lesão do tecido (isquemia)– morte celular
Todos esses fatores causam a liberação de ligantes enviando sinais para a célula do tecido envolvido
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Sistema Controle do Ciclo Celular Dispositivo Bioquímico
Baseado em proteínas proteinoquinase dependente de ciclina ciclinas:
G1 Mitótica
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Pontos de controle estratégico – G1
– G2
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Pontos que caracterizam a Mitose Condensação dos cromossomos
Importância: Evita o emaranhamento ou rompimento do material genético durante sua distribuição às células filhas.
Conseqüência: Inativação da cromatina
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Fuso mitótico– Microtúbulos– proteínas associadas
Anel contráctil– actina – miosina
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Quais as conseqüências observadas nas células ao entrar em Mitose?
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Acúmulo gradativo de ciclinas mitóticas e sua ligação para formar o MPF
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O que faz o MPF?
Fosforilação de proteínas – cromossomos condensados – envelope nuclear desorganizado
atua nos resíduos de serina da lamina interna– separação dos filamentos em dímeros
– R.E. e Golgi fragmentados – perda de adesão célula-célula e à matriz – citoesqueleto com movimentos organizados formam o
fuso
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COMO?
Diretamente por fosforilação dos componentes chaves
Indiretamente por fosforilação que ativam outras
proteinoquinase
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Se o sistema controle ativa o desencadeador da fase M antes da replicação do DNA ter sido completada, a célula entra em mitose suicida com seus cromossomos parcialmente duplicados
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O QUE LEVA A CÉLULA ENTRAR EM MITOSE?• Acumulo gradativo de ciclinas mitóticas• Sua ligação para formar o MPF
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O QUE LEVA A CÉLULA A SAIR DA MITOSE? • Inativação do MPF pela degradação de ciclinas
(metáfase-anáfase)
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RESUMO DO FUNCIONAMENTO DOSISTEMA CONTROLE
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ACÚMULO GRADATIVO DE CICLINA
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AGE
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ESTOPIM
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DETONAR UMA EXPLOSÃO AUTOCATALÍTICA DO MPF
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DESENCADEIA OS PASSOS INICIAIS DA MITOSE
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DESTRUIÇÃO DAS CICLINAS
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CESSA A ATIVIDADE DO MPF
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RECOMEÇA O ACÚMULO DE CICLINA
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MITOSE
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