Management of premalignant lesions of gastric cancer A survey of European Gastroenterologists Class...

Management of premalignant lesions of gastric cancer

A survey of European Gastroenterologists

Class 16

Porto, 2008/2009Professor Doutor Altamiro da Costa Pereira

Authors: Ana Silva, Andreia Carvalho, Carlos Laranja, Cláudia Leite, Daniel Oliveira, Francisco Silva, Henrique Sousa, Joana Matos, João Cardoso, Luís Vale, Mariana Santiago, Pedro Morais, Renato Ramos, Rui Loureiro, Tatiana Salazar;

Supervisors: Prof. Doutor Mário Ribeiro e Dr. Ricardo Santos

INTRODUCTION

RESEARCH QUESTION

PARTICIPANTSAND METHODS


RESULTS

REFERENCES

AIMS

Premalignant

lesions

Gastric Cancer

High mortal

ity and

morbidity

Lack of

practice

recommendations

Worldwide

incidence

INTRODUCTION


Premalignant lesions

Atrophic chronic gastritis (ACG)Intestinal metaplasia (IM)Dysplasia (Dys)


INTRODUCTION

Which are the main options concerning

diagnosis, monitoring and treatment of

premalignant lesions of gastric cancer

that are being taken by European

Gastroenterologists?


RESEARCH QUESTION


To assess the practice in terms of

diagnosis, monitoring and treatment of

premalignant lesions of gastric cancer

To compile these management options

into a database

AIMS


PARTICIPANTS AND METHODS

Type of study

- observational and cross-sectional

Participants’ selection

Data collection

Variables description

Statistical analysis of data

Sampling


Target Population: Gastroenterologists

performing research in this field

Articles search

Authors’ contacts database

Participants’ selection



Sent by e-mail

Opened ended questionsClosed ended questions


Data collection

Query

http://newdbserver.med.up.pt/projext/medquest/recolhas/im2009_turma16/index.php?niq=87

• Dependent variables:– Management options taken

• Independent variables:– Type of lesions– Author/Department– Place of work– …



Variables description

Categorical variables


• Descriptive statistics- absolute and relative frequencies- 95% confidence intervals

• Inferencial statistics - Chi-square/contigency tables(or Fisher’s)- statistical significance – 0.05


Using SPSSStatistical analysis

RESULTS

Nr. of e-mails sent 132

Nr. of e-mails delivered: 132

Nr. of e-mails not delivered: 0

Answered: 16 No response yet: 116


Fluxogram1: E-mails response

RESULTS


Image1: SPSS database image


RESULTS

0 - Does your answers reflect your own practice or your department(s)?

Total N %

Query 14

Valid cases 14 100

Missing 0 0

Description N % Cum. %Cum.

Department 7 50 7 50

My own 7 50 14 100

Table 1: Question results

RESULTS


Pratical attitudes

Diagnosis Follow-up Erradication H. Pylori

Atrophic chronic gastritis (ACG)

[a;b]

Intestinal metaplasia (IM)

Dysplasia

(Dys)

Low grade

High grade

Table 2: Summary results

• Low response rate- Until now we have 12.12% of

response

Send query second time


RESULTS

Problems and limitations


1. Contacts’ database

2. Querys’ answers 3. Management options’ database

4. Online publication

RESULTS

[1] Lockead P, El-Omar EM. Gastric Cancer. Br Med Bull. 2008;85:87-100.[2] Parkin DM, Bray F, Ferlay J, Pisani P..Global cancer statistics, 2002. CA Cancer J Clin. 2005 Mar-Apr;55(2):74-108.[3] Stomach (Gastric) Cancer [Internet]. Bethesda: National Cancer Institute. Estimated new cases and deaths from stomach cancer in the United States in 2008; [cited 2008 November 1]; [1 screen]. Available from: http://www.cancer.gov/cancertopics/types/stomach4] Plano Nacional de Prevenção e Controlo das Doenças Oncológicas 2007/2010, Dezembro 2007.[5] Sugiyama T, Asaka M. Helicobacter pylori infection and gastric cancer. Med Electron Microsc. 2004 Sep;37(3):149-57.[6] Menaker RJ, Sharaf AA, Jones NL. Helicobacter pylori infection and gastric cancer: host, bug, environment, or all three?. Curr Gastroenterol Rep. 2004 Dec;6(6):429-35.[7] de Vries AC, Haringsma J, Kuipers EJ. The detection, surveillance and treatment of premalignat gastric lesions related to Helicobacter pylori infection. Helicobacter 2007; 12: 1-15.[8] Bowles MJ, Benjamin IS. ABC of the upper gastrointestinal tract. Cancer of the stomach and pancreas. BMJ 2001;323:1413–6[9] Witold Bartnik. Clinical aspects of Helicobacter pylori infection. Pol Arch Med Wewn, 2008; 118 (7-8): 426-430 [10] M Dinis-Ribeiro, A Costa-Pereira, C Lopes, L Moreira-Dias. Guidelines for surveillance of patients with atrophic chronic gastritis and intestinal metaplasia in stomach would be welcome! Helicobacter . 2007 Feb;12(1):1-15


REFERENCES

http://www.ncbi.nlm.nih.gov/pubmed/15761078?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

Management of premalignant lesions of gastric cancer A survey of European Gastroenterologists Class...

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