OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO...

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21O. Curso de Ozonioterapia 9/24/2016 Autor: Arnoldo de Souza 1 Dr. Arnoldo de Souza OZONIOTERAPIA EM CARDIOLOGIA 2 OZONIOTERAPIA EM CARDIOLOGIA Oxigênio/Ozonioterapia pode melhorar doenças cardiovasculares ?

Transcript of OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO...

Page 1: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 1

Dr Arnoldo de Souza OZONIOTERAPIA EM CARDIOLOGIA

2

OZONIOTERAPIA EM CARDIOLOGIA

OxigecircnioOzonioterapia

pode melhorar doenccedilas cardiovasculares

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 2

3

OZONIOTERAPIA EM CARDIOLOGIA

Envelhecimento Populacional

Isquemia crocircnica

Ins Cardiacuteaca Crocircnica

Isquemia cerebral

Degeneraccedilatildeo Macular

4

SIMPATICOTONIA STRESS

Aterosclerose

Teorias SNS elevado Stress Fumo Poluiccedilatildeo

Dieta rica em CH

As comorbidades tb cursam com SNS elevado

DMHAS Apneacuteia do sono Disfunccedilatildeo ereacutetil

Aumento de aacutec laacutetico =Aumento de lipiacutedios

intracoronaacuterios

Lacto acidoseAterosclerose

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 3

5

ATEROSCLEROSE TEORIAS

Jurgen

Trecircs compartimentos

Matriz extracelular

Reserva de O2

Metabolismo

PH

SNA

6

ATEROSCLEROSE TEORIAS

Inflamaccedilatildeo

Isquemia crocircnica

Degeneraccedilatildeo tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 4

7

BASIC REGULATION OF THE CELL-METABOLISM

synthesis metabolism

energymetabolism

anabolic cataboliccortisol thyroxin(catabolic effect)

HGH anabpeptids(anabolic effect)

SHOCK STRESSunstabile regulatory equilibrium

= state of metabolism = anabolic derailment catabolic derailment

8

Equiliacutebrio Instaacutevel

bullA regulaccedilatildeo do metabolismo celular

soacute eacute possiacutevel quando e se todos os

3 reguladores o anaboacutelico HGH (

hormocircnio do crescimento) bem

como os 2 hormocircnios cataboacutelicos

cortisol + tiroxina estatildeo presentes

na ceacutelula em seu iacutentimo e juntos ao

mesmo tempo (atJSchole)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 5

9

Equiliacutebrio Instaacutevel

O atual

estado do metabolismo

reflete o

potential redox

10

Equiliacutebrio Instaacutevel

bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica

bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)

bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 6

11

Desvio Anaboacutelico significa

- baixa velocidade de siacutentese(energia )

- divisatildeo celular tardia ceacutel grande

- epi e endoteacutelio tornam-se espessos

- resultado cel grande e sem funccedilatildeo

- oxidaccedilatildeo e hidroacutelise diminuem

12

OZONIOTERAPIA EM CARDIOLOGIA

Desvio cataboacutelico significa

-

- oxidaccedilatildeo e aumento de radicais

livres

- divisatildeo celular prematura

- epiteacutelio e endoteacutelio mais finos

- resultado celulaspequenas sem

funccedilatildeo adequada

- oxidaccedilatildeo e hidrolise se elevam

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Autor Arnoldo de Souza 7

13

OZONIOTERAPIA EM CARDIOLOGIA

Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares

Inflamaccedilatildeo

Isquemia

14

MECANISMO DE ACcedilAtildeO DO OZOcircNIO

O3

P

L

A

SM

A

ROS

( H2O2)

LOPs

ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2

LINFOacuteCITOS Ativaccedilatildeo da Imunidade

PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento

Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico

MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco

Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 8

15

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO

Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria

16

O AUMENTO DA VELOCIDADE DA

GLICOacuteLISE NO ERITROacuteCITO Eacute

ACOMPANHADO DE UM

SIGNIFICATIVO AUMENTO NO

INTERCAcircMBIO DE IacuteONS SOacuteDIO E

POTAacuteSSIO OS QUAIS SAtildeO

RESPONSAacuteVEIS POR MANTER O

POTENCIAL ELEacuteTRICO DE

MEMBRANA

ATIVA METABOLISMO DAS HEMAacuteCIAS

AS DOENCcedilAS ARTERIAIS OCLUSIVAS

ESTAtildeO RELACIONADAS COM A REDUCcedilAO

DO POTENCIAL DE MEMBRANA

A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS

PELO OZOcircNIO E SEUS PRODUTOS

FAVORECE A RESTAURACcedilAtildeO DO

POTENCIAL DE ACcedilAtildeO DA MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 9

17

MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL

MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA

FRAGMENTO DA

ANAacuteLISE DO SANGUE

DE UMA PESSOA

SAUDAacuteVEL E

MICROSCOacutePIO DIGITAL

HOLOGRAacuteFICO

INTERFEREcircNCIAL

18

TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL

Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov

ESQUEMA DE DETERMINACcedilAtildeO DO

COEFICIENTE DE ESFERICIDADE

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 10

19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

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Autor Arnoldo de Souza 11

21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

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Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

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Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

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Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

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Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

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Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

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33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

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Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

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Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

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Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

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Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

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Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

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Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

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Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

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Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

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Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

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63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

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69

70

Adelir Augusto Sesconete

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71

72

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74

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76

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78

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80

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82

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84

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85

86

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88

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90

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94

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96

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100

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102

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104

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106

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108

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110

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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121

122

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Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

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Autor Arnoldo de Souza 64

127

Page 2: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 2

3

OZONIOTERAPIA EM CARDIOLOGIA

Envelhecimento Populacional

Isquemia crocircnica

Ins Cardiacuteaca Crocircnica

Isquemia cerebral

Degeneraccedilatildeo Macular

4

SIMPATICOTONIA STRESS

Aterosclerose

Teorias SNS elevado Stress Fumo Poluiccedilatildeo

Dieta rica em CH

As comorbidades tb cursam com SNS elevado

DMHAS Apneacuteia do sono Disfunccedilatildeo ereacutetil

Aumento de aacutec laacutetico =Aumento de lipiacutedios

intracoronaacuterios

Lacto acidoseAterosclerose

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 3

5

ATEROSCLEROSE TEORIAS

Jurgen

Trecircs compartimentos

Matriz extracelular

Reserva de O2

Metabolismo

PH

SNA

6

ATEROSCLEROSE TEORIAS

Inflamaccedilatildeo

Isquemia crocircnica

Degeneraccedilatildeo tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 4

7

BASIC REGULATION OF THE CELL-METABOLISM

synthesis metabolism

energymetabolism

anabolic cataboliccortisol thyroxin(catabolic effect)

HGH anabpeptids(anabolic effect)

SHOCK STRESSunstabile regulatory equilibrium

= state of metabolism = anabolic derailment catabolic derailment

8

Equiliacutebrio Instaacutevel

bullA regulaccedilatildeo do metabolismo celular

soacute eacute possiacutevel quando e se todos os

3 reguladores o anaboacutelico HGH (

hormocircnio do crescimento) bem

como os 2 hormocircnios cataboacutelicos

cortisol + tiroxina estatildeo presentes

na ceacutelula em seu iacutentimo e juntos ao

mesmo tempo (atJSchole)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 5

9

Equiliacutebrio Instaacutevel

O atual

estado do metabolismo

reflete o

potential redox

10

Equiliacutebrio Instaacutevel

bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica

bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)

bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 6

11

Desvio Anaboacutelico significa

- baixa velocidade de siacutentese(energia )

- divisatildeo celular tardia ceacutel grande

- epi e endoteacutelio tornam-se espessos

- resultado cel grande e sem funccedilatildeo

- oxidaccedilatildeo e hidroacutelise diminuem

12

OZONIOTERAPIA EM CARDIOLOGIA

Desvio cataboacutelico significa

-

- oxidaccedilatildeo e aumento de radicais

livres

- divisatildeo celular prematura

- epiteacutelio e endoteacutelio mais finos

- resultado celulaspequenas sem

funccedilatildeo adequada

- oxidaccedilatildeo e hidrolise se elevam

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 7

13

OZONIOTERAPIA EM CARDIOLOGIA

Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares

Inflamaccedilatildeo

Isquemia

14

MECANISMO DE ACcedilAtildeO DO OZOcircNIO

O3

P

L

A

SM

A

ROS

( H2O2)

LOPs

ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2

LINFOacuteCITOS Ativaccedilatildeo da Imunidade

PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento

Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico

MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco

Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 8

15

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO

Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria

16

O AUMENTO DA VELOCIDADE DA

GLICOacuteLISE NO ERITROacuteCITO Eacute

ACOMPANHADO DE UM

SIGNIFICATIVO AUMENTO NO

INTERCAcircMBIO DE IacuteONS SOacuteDIO E

POTAacuteSSIO OS QUAIS SAtildeO

RESPONSAacuteVEIS POR MANTER O

POTENCIAL ELEacuteTRICO DE

MEMBRANA

ATIVA METABOLISMO DAS HEMAacuteCIAS

AS DOENCcedilAS ARTERIAIS OCLUSIVAS

ESTAtildeO RELACIONADAS COM A REDUCcedilAO

DO POTENCIAL DE MEMBRANA

A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS

PELO OZOcircNIO E SEUS PRODUTOS

FAVORECE A RESTAURACcedilAtildeO DO

POTENCIAL DE ACcedilAtildeO DA MEMBRANA

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Autor Arnoldo de Souza 9

17

MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL

MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA

FRAGMENTO DA

ANAacuteLISE DO SANGUE

DE UMA PESSOA

SAUDAacuteVEL E

MICROSCOacutePIO DIGITAL

HOLOGRAacuteFICO

INTERFEREcircNCIAL

18

TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL

Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov

ESQUEMA DE DETERMINACcedilAtildeO DO

COEFICIENTE DE ESFERICIDADE

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Autor Arnoldo de Souza 10

19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 11

21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

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Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

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73

74

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Autor Arnoldo de Souza 38

75

76

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Autor Arnoldo de Souza 39

77

78

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Autor Arnoldo de Souza 40

79

80

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Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

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Autor Arnoldo de Souza 45

89

90

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Autor Arnoldo de Souza 46

91

92

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Autor Arnoldo de Souza 47

93

94

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Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

97

98

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Autor Arnoldo de Souza 50

99

100

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Autor Arnoldo de Souza 51

101

102

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Autor Arnoldo de Souza 52

103

104

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Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

107

108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 3: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 3

5

ATEROSCLEROSE TEORIAS

Jurgen

Trecircs compartimentos

Matriz extracelular

Reserva de O2

Metabolismo

PH

SNA

6

ATEROSCLEROSE TEORIAS

Inflamaccedilatildeo

Isquemia crocircnica

Degeneraccedilatildeo tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 4

7

BASIC REGULATION OF THE CELL-METABOLISM

synthesis metabolism

energymetabolism

anabolic cataboliccortisol thyroxin(catabolic effect)

HGH anabpeptids(anabolic effect)

SHOCK STRESSunstabile regulatory equilibrium

= state of metabolism = anabolic derailment catabolic derailment

8

Equiliacutebrio Instaacutevel

bullA regulaccedilatildeo do metabolismo celular

soacute eacute possiacutevel quando e se todos os

3 reguladores o anaboacutelico HGH (

hormocircnio do crescimento) bem

como os 2 hormocircnios cataboacutelicos

cortisol + tiroxina estatildeo presentes

na ceacutelula em seu iacutentimo e juntos ao

mesmo tempo (atJSchole)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 5

9

Equiliacutebrio Instaacutevel

O atual

estado do metabolismo

reflete o

potential redox

10

Equiliacutebrio Instaacutevel

bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica

bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)

bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 6

11

Desvio Anaboacutelico significa

- baixa velocidade de siacutentese(energia )

- divisatildeo celular tardia ceacutel grande

- epi e endoteacutelio tornam-se espessos

- resultado cel grande e sem funccedilatildeo

- oxidaccedilatildeo e hidroacutelise diminuem

12

OZONIOTERAPIA EM CARDIOLOGIA

Desvio cataboacutelico significa

-

- oxidaccedilatildeo e aumento de radicais

livres

- divisatildeo celular prematura

- epiteacutelio e endoteacutelio mais finos

- resultado celulaspequenas sem

funccedilatildeo adequada

- oxidaccedilatildeo e hidrolise se elevam

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 7

13

OZONIOTERAPIA EM CARDIOLOGIA

Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares

Inflamaccedilatildeo

Isquemia

14

MECANISMO DE ACcedilAtildeO DO OZOcircNIO

O3

P

L

A

SM

A

ROS

( H2O2)

LOPs

ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2

LINFOacuteCITOS Ativaccedilatildeo da Imunidade

PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento

Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico

MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco

Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 8

15

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO

Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria

16

O AUMENTO DA VELOCIDADE DA

GLICOacuteLISE NO ERITROacuteCITO Eacute

ACOMPANHADO DE UM

SIGNIFICATIVO AUMENTO NO

INTERCAcircMBIO DE IacuteONS SOacuteDIO E

POTAacuteSSIO OS QUAIS SAtildeO

RESPONSAacuteVEIS POR MANTER O

POTENCIAL ELEacuteTRICO DE

MEMBRANA

ATIVA METABOLISMO DAS HEMAacuteCIAS

AS DOENCcedilAS ARTERIAIS OCLUSIVAS

ESTAtildeO RELACIONADAS COM A REDUCcedilAO

DO POTENCIAL DE MEMBRANA

A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS

PELO OZOcircNIO E SEUS PRODUTOS

FAVORECE A RESTAURACcedilAtildeO DO

POTENCIAL DE ACcedilAtildeO DA MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 9

17

MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL

MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA

FRAGMENTO DA

ANAacuteLISE DO SANGUE

DE UMA PESSOA

SAUDAacuteVEL E

MICROSCOacutePIO DIGITAL

HOLOGRAacuteFICO

INTERFEREcircNCIAL

18

TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL

Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov

ESQUEMA DE DETERMINACcedilAtildeO DO

COEFICIENTE DE ESFERICIDADE

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 10

19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 11

21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 4: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 4

7

BASIC REGULATION OF THE CELL-METABOLISM

synthesis metabolism

energymetabolism

anabolic cataboliccortisol thyroxin(catabolic effect)

HGH anabpeptids(anabolic effect)

SHOCK STRESSunstabile regulatory equilibrium

= state of metabolism = anabolic derailment catabolic derailment

8

Equiliacutebrio Instaacutevel

bullA regulaccedilatildeo do metabolismo celular

soacute eacute possiacutevel quando e se todos os

3 reguladores o anaboacutelico HGH (

hormocircnio do crescimento) bem

como os 2 hormocircnios cataboacutelicos

cortisol + tiroxina estatildeo presentes

na ceacutelula em seu iacutentimo e juntos ao

mesmo tempo (atJSchole)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 5

9

Equiliacutebrio Instaacutevel

O atual

estado do metabolismo

reflete o

potential redox

10

Equiliacutebrio Instaacutevel

bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica

bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)

bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 6

11

Desvio Anaboacutelico significa

- baixa velocidade de siacutentese(energia )

- divisatildeo celular tardia ceacutel grande

- epi e endoteacutelio tornam-se espessos

- resultado cel grande e sem funccedilatildeo

- oxidaccedilatildeo e hidroacutelise diminuem

12

OZONIOTERAPIA EM CARDIOLOGIA

Desvio cataboacutelico significa

-

- oxidaccedilatildeo e aumento de radicais

livres

- divisatildeo celular prematura

- epiteacutelio e endoteacutelio mais finos

- resultado celulaspequenas sem

funccedilatildeo adequada

- oxidaccedilatildeo e hidrolise se elevam

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 7

13

OZONIOTERAPIA EM CARDIOLOGIA

Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares

Inflamaccedilatildeo

Isquemia

14

MECANISMO DE ACcedilAtildeO DO OZOcircNIO

O3

P

L

A

SM

A

ROS

( H2O2)

LOPs

ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2

LINFOacuteCITOS Ativaccedilatildeo da Imunidade

PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento

Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico

MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco

Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 8

15

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO

Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria

16

O AUMENTO DA VELOCIDADE DA

GLICOacuteLISE NO ERITROacuteCITO Eacute

ACOMPANHADO DE UM

SIGNIFICATIVO AUMENTO NO

INTERCAcircMBIO DE IacuteONS SOacuteDIO E

POTAacuteSSIO OS QUAIS SAtildeO

RESPONSAacuteVEIS POR MANTER O

POTENCIAL ELEacuteTRICO DE

MEMBRANA

ATIVA METABOLISMO DAS HEMAacuteCIAS

AS DOENCcedilAS ARTERIAIS OCLUSIVAS

ESTAtildeO RELACIONADAS COM A REDUCcedilAO

DO POTENCIAL DE MEMBRANA

A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS

PELO OZOcircNIO E SEUS PRODUTOS

FAVORECE A RESTAURACcedilAtildeO DO

POTENCIAL DE ACcedilAtildeO DA MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 9

17

MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL

MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA

FRAGMENTO DA

ANAacuteLISE DO SANGUE

DE UMA PESSOA

SAUDAacuteVEL E

MICROSCOacutePIO DIGITAL

HOLOGRAacuteFICO

INTERFEREcircNCIAL

18

TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL

Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov

ESQUEMA DE DETERMINACcedilAtildeO DO

COEFICIENTE DE ESFERICIDADE

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 10

19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 11

21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

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59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

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61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

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63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

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67

68

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69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

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71

72

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74

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76

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77

78

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79

80

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81

82

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83

84

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85

86

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87

88

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90

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92

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94

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95

96

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97

98

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Autor Arnoldo de Souza 50

99

100

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101

102

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104

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106

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109

110

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

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Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

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Autor Arnoldo de Souza 60

119

120

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121

122

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123

124

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125

126

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Autor Arnoldo de Souza 64

127

Page 5: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 5

9

Equiliacutebrio Instaacutevel

O atual

estado do metabolismo

reflete o

potential redox

10

Equiliacutebrio Instaacutevel

bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica

bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)

bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 6

11

Desvio Anaboacutelico significa

- baixa velocidade de siacutentese(energia )

- divisatildeo celular tardia ceacutel grande

- epi e endoteacutelio tornam-se espessos

- resultado cel grande e sem funccedilatildeo

- oxidaccedilatildeo e hidroacutelise diminuem

12

OZONIOTERAPIA EM CARDIOLOGIA

Desvio cataboacutelico significa

-

- oxidaccedilatildeo e aumento de radicais

livres

- divisatildeo celular prematura

- epiteacutelio e endoteacutelio mais finos

- resultado celulaspequenas sem

funccedilatildeo adequada

- oxidaccedilatildeo e hidrolise se elevam

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 7

13

OZONIOTERAPIA EM CARDIOLOGIA

Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares

Inflamaccedilatildeo

Isquemia

14

MECANISMO DE ACcedilAtildeO DO OZOcircNIO

O3

P

L

A

SM

A

ROS

( H2O2)

LOPs

ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2

LINFOacuteCITOS Ativaccedilatildeo da Imunidade

PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento

Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico

MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco

Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 8

15

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO

Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria

16

O AUMENTO DA VELOCIDADE DA

GLICOacuteLISE NO ERITROacuteCITO Eacute

ACOMPANHADO DE UM

SIGNIFICATIVO AUMENTO NO

INTERCAcircMBIO DE IacuteONS SOacuteDIO E

POTAacuteSSIO OS QUAIS SAtildeO

RESPONSAacuteVEIS POR MANTER O

POTENCIAL ELEacuteTRICO DE

MEMBRANA

ATIVA METABOLISMO DAS HEMAacuteCIAS

AS DOENCcedilAS ARTERIAIS OCLUSIVAS

ESTAtildeO RELACIONADAS COM A REDUCcedilAO

DO POTENCIAL DE MEMBRANA

A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS

PELO OZOcircNIO E SEUS PRODUTOS

FAVORECE A RESTAURACcedilAtildeO DO

POTENCIAL DE ACcedilAtildeO DA MEMBRANA

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Autor Arnoldo de Souza 9

17

MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL

MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA

FRAGMENTO DA

ANAacuteLISE DO SANGUE

DE UMA PESSOA

SAUDAacuteVEL E

MICROSCOacutePIO DIGITAL

HOLOGRAacuteFICO

INTERFEREcircNCIAL

18

TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL

Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov

ESQUEMA DE DETERMINACcedilAtildeO DO

COEFICIENTE DE ESFERICIDADE

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19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

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21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

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23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

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25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

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Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 6: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 6

11

Desvio Anaboacutelico significa

- baixa velocidade de siacutentese(energia )

- divisatildeo celular tardia ceacutel grande

- epi e endoteacutelio tornam-se espessos

- resultado cel grande e sem funccedilatildeo

- oxidaccedilatildeo e hidroacutelise diminuem

12

OZONIOTERAPIA EM CARDIOLOGIA

Desvio cataboacutelico significa

-

- oxidaccedilatildeo e aumento de radicais

livres

- divisatildeo celular prematura

- epiteacutelio e endoteacutelio mais finos

- resultado celulaspequenas sem

funccedilatildeo adequada

- oxidaccedilatildeo e hidrolise se elevam

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 7

13

OZONIOTERAPIA EM CARDIOLOGIA

Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares

Inflamaccedilatildeo

Isquemia

14

MECANISMO DE ACcedilAtildeO DO OZOcircNIO

O3

P

L

A

SM

A

ROS

( H2O2)

LOPs

ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2

LINFOacuteCITOS Ativaccedilatildeo da Imunidade

PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento

Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico

MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco

Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 8

15

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO

Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria

16

O AUMENTO DA VELOCIDADE DA

GLICOacuteLISE NO ERITROacuteCITO Eacute

ACOMPANHADO DE UM

SIGNIFICATIVO AUMENTO NO

INTERCAcircMBIO DE IacuteONS SOacuteDIO E

POTAacuteSSIO OS QUAIS SAtildeO

RESPONSAacuteVEIS POR MANTER O

POTENCIAL ELEacuteTRICO DE

MEMBRANA

ATIVA METABOLISMO DAS HEMAacuteCIAS

AS DOENCcedilAS ARTERIAIS OCLUSIVAS

ESTAtildeO RELACIONADAS COM A REDUCcedilAO

DO POTENCIAL DE MEMBRANA

A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS

PELO OZOcircNIO E SEUS PRODUTOS

FAVORECE A RESTAURACcedilAtildeO DO

POTENCIAL DE ACcedilAtildeO DA MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 9

17

MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL

MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA

FRAGMENTO DA

ANAacuteLISE DO SANGUE

DE UMA PESSOA

SAUDAacuteVEL E

MICROSCOacutePIO DIGITAL

HOLOGRAacuteFICO

INTERFEREcircNCIAL

18

TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL

Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov

ESQUEMA DE DETERMINACcedilAtildeO DO

COEFICIENTE DE ESFERICIDADE

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 10

19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 11

21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 7: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 7

13

OZONIOTERAPIA EM CARDIOLOGIA

Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares

Inflamaccedilatildeo

Isquemia

14

MECANISMO DE ACcedilAtildeO DO OZOcircNIO

O3

P

L

A

SM

A

ROS

( H2O2)

LOPs

ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2

LINFOacuteCITOS Ativaccedilatildeo da Imunidade

PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento

Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico

MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco

Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 8

15

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO

Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria

16

O AUMENTO DA VELOCIDADE DA

GLICOacuteLISE NO ERITROacuteCITO Eacute

ACOMPANHADO DE UM

SIGNIFICATIVO AUMENTO NO

INTERCAcircMBIO DE IacuteONS SOacuteDIO E

POTAacuteSSIO OS QUAIS SAtildeO

RESPONSAacuteVEIS POR MANTER O

POTENCIAL ELEacuteTRICO DE

MEMBRANA

ATIVA METABOLISMO DAS HEMAacuteCIAS

AS DOENCcedilAS ARTERIAIS OCLUSIVAS

ESTAtildeO RELACIONADAS COM A REDUCcedilAO

DO POTENCIAL DE MEMBRANA

A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS

PELO OZOcircNIO E SEUS PRODUTOS

FAVORECE A RESTAURACcedilAtildeO DO

POTENCIAL DE ACcedilAtildeO DA MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 9

17

MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL

MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA

FRAGMENTO DA

ANAacuteLISE DO SANGUE

DE UMA PESSOA

SAUDAacuteVEL E

MICROSCOacutePIO DIGITAL

HOLOGRAacuteFICO

INTERFEREcircNCIAL

18

TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL

Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov

ESQUEMA DE DETERMINACcedilAtildeO DO

COEFICIENTE DE ESFERICIDADE

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 10

19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 11

21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

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Adelir Augusto Sesconete

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72

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111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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121

122

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123

124

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125

126

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Autor Arnoldo de Souza 64

127

Page 8: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 8

15

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO

Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria

16

O AUMENTO DA VELOCIDADE DA

GLICOacuteLISE NO ERITROacuteCITO Eacute

ACOMPANHADO DE UM

SIGNIFICATIVO AUMENTO NO

INTERCAcircMBIO DE IacuteONS SOacuteDIO E

POTAacuteSSIO OS QUAIS SAtildeO

RESPONSAacuteVEIS POR MANTER O

POTENCIAL ELEacuteTRICO DE

MEMBRANA

ATIVA METABOLISMO DAS HEMAacuteCIAS

AS DOENCcedilAS ARTERIAIS OCLUSIVAS

ESTAtildeO RELACIONADAS COM A REDUCcedilAO

DO POTENCIAL DE MEMBRANA

A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS

PELO OZOcircNIO E SEUS PRODUTOS

FAVORECE A RESTAURACcedilAtildeO DO

POTENCIAL DE ACcedilAtildeO DA MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 9

17

MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL

MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA

FRAGMENTO DA

ANAacuteLISE DO SANGUE

DE UMA PESSOA

SAUDAacuteVEL E

MICROSCOacutePIO DIGITAL

HOLOGRAacuteFICO

INTERFEREcircNCIAL

18

TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL

Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov

ESQUEMA DE DETERMINACcedilAtildeO DO

COEFICIENTE DE ESFERICIDADE

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 10

19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 11

21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

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53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

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55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

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57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

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59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

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61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

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63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

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67

68

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69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

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71

72

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74

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76

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77

78

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80

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82

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83

84

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85

86

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88

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90

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94

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95

96

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97

98

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99

100

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101

102

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103

104

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105

106

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108

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109

110

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111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

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115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

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117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

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119

120

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121

122

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123

124

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125

126

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127

Page 9: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 9

17

MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL

MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA

FRAGMENTO DA

ANAacuteLISE DO SANGUE

DE UMA PESSOA

SAUDAacuteVEL E

MICROSCOacutePIO DIGITAL

HOLOGRAacuteFICO

INTERFEREcircNCIAL

18

TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL

Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov

ESQUEMA DE DETERMINACcedilAtildeO DO

COEFICIENTE DE ESFERICIDADE

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19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

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21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

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23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

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25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

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27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

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29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

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31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

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33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

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35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

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37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

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39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

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Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

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Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

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69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

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71

72

21O Curso de Ozonioterapia 9242016

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73

74

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75

76

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Autor Arnoldo de Souza 39

77

78

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Autor Arnoldo de Souza 40

79

80

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Autor Arnoldo de Souza 41

81

82

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Autor Arnoldo de Souza 42

83

84

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Autor Arnoldo de Souza 43

85

86

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Autor Arnoldo de Souza 44

87

88

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Autor Arnoldo de Souza 45

89

90

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Autor Arnoldo de Souza 46

91

92

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93

94

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Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

97

98

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Autor Arnoldo de Souza 50

99

100

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Autor Arnoldo de Souza 51

101

102

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103

104

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Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

107

108

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109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 10: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 10

19

ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA

20

EFEITOS DO O3 NAS HEMAacuteCIAS ndash

Resumindo

MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL

FENOcircMENO ANTISLUDGING

(SEDIMENTACcedilAtildeO)

FLEXIBILIDADE DE MEMBRANA

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 11

21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

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73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

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Autor Arnoldo de Souza 39

77

78

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Autor Arnoldo de Souza 40

79

80

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Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

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Autor Arnoldo de Souza 45

89

90

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Autor Arnoldo de Souza 46

91

92

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Autor Arnoldo de Souza 47

93

94

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Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

97

98

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Autor Arnoldo de Souza 50

99

100

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Autor Arnoldo de Souza 51

101

102

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Autor Arnoldo de Souza 52

103

104

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Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

107

108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 11: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 11

21

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

IMUNOLOacuteGICO

Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral

Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria

22

CASCATA INFLAMATOacuteRIA

bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES

bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS

bullCITOCINAS INDUZEM RESPOSTAS CELULARES

Adaptado dos slides Prof Z Fahmy Cuba 2010

Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271

Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161

B Cell

T Cell

Macrophage

Pannus

Cartilage

TNF

IL-1

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

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Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

97

98

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Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

107

108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 12: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 12

23

ACcedilAtildeO DAS CITOCINAS

bullMEDIADORES DE FUNCcedilOtildeES CELULARES

bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS

bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR

Adaptado dos slides Prof Z Fahmy Cuba 2010

Arend WP et al Textbook of Rheumatology1993 227-247

Baumgartner SW et al South Med J 200093753-759

Moreland LW Cleve Clin J Med199966367-374

TNF

IL-1

Cell-surface

TNF receptor

Soluble

TNF receptor

24

REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS

PROacute-INFLAMATOacuteRIAS

Plt001 vs air

Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 13: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 13

25

O3 INIBE TNF-Α E AUMENTA

CEacuteLULAS ENDOTELIAIS

26

OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO

METABOacuteLICO

bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia

bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)

bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres

bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)

bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular

bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 14: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 14

27

REGULADOR DO METABOLISMO

OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS

MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS

INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS

(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)

28

OZOcircNIO FATORES DE RISCO

bullREDUZ

COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)

HOMOCISTEIacuteNA (SIMONETTI V 2006)

bullAUMENTA

HDL (BISETTI 1988)

NO 14-16 H DEPOIS DA GAET (BOCCI 1998)

EXPRESSAtildeO DA HEMOXIGENASE 1

LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 15: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 15

29

PROPRIEDADES DO OZONIO

bull Bactericida

bull Fungicida

bull Virostaacutetico

bull Melhora a reaccedilatildeo imunoloacutegica

bull Melhora a reologia do sangue

bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias

bull Melhora a oxigenaccedilatildeo dos tecidos

bull Aumento do pO2 arterial

bull Liberaccedilatildeo de hematopoietina

bull Aumenta a atividade antioxidante

30

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS NEURODEGENERATIVAS

ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias

Accedilatildeo do Ozocircnio

Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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121

122

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123

124

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125

126

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127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 16

31

ACcedilOtildeES DA OZONIOTERAPIA

DOENCcedilAS ISQUEcircMICAS

Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa

Accedilatildeo do Ozocircnio

Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo

Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo

Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese

Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)

32

Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento

sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

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Autor Arnoldo de Souza 40

79

80

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Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

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Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

97

98

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Autor Arnoldo de Souza 50

99

100

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Autor Arnoldo de Souza 51

101

102

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Autor Arnoldo de Souza 52

103

104

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Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

107

108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 17: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 17

33

PRINCIPAIS CAUSAS Aterosclerose

Trombose

Tromboembolismo

Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano

34

CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na

sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da

funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias

anormalidades bioquiacutemicas ultraestruturais e vasculares

A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de

RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 18: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 18

35

Abordagens para eliminaccedilaotilde

dos RL na

IsquemiaReperfusatildeo Varredores de

RL O2macrbull

SOD

H2O2Catalase

Peroxidase

OHbull

ManitolDMSO

Inibidores da XO

Alopurinol

Quelantes de

Ferro

Deferoxamina

Inibidores leucocitaacuterios AdenosinaIbuprofeno

AO naturais α-Tocoferol CoQ10

DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores

Precursores de GSH N-Acetilcisteiacutena

36

O3Preserva o equiliacutebrio

antioxidanteproacute-oxidante essencial para

a vida e estimula o sistema de defesa

antioxidante endoacutegeno

Previne o dano de arquitetura orgacircnica

induzido pela isquemia

Diminui a acidose laacutetica induzida pela

isquemia

Pode preservar ATP

Protege contra inflamaccedilatildeo induzida

pela isquemia evitando o recrutamento

e a ativaccedilatildeo de neutroacutefilos que geram

EROS e estimulam o dano tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 19: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 19

37

Bases biofiacutesicas da Ozonioterapia

Ao mesmo tempo vivemos em 2 espaccedilos

Espaccedilo de Minkowski

Espaccedilo Kosyrev

espaccedilocom

massae

energia

MATEacuteRIArealidadeexpliacutecita

1a-6a dimensotildees deBHeim

ESPIRITOinfor-maccedilatildeo

impliacutecita

7a-12a dimensatildeo deBHeim

38

Bases biofiacutesicas da

Ozonioterapia

SER Humano sendo como um processo coacutesmico

dimensotildees

1

2

3

4

5

6

espaccedilo 3-D-

tempo

possi-bilidades

reali-zaccedilatildeo

espaccediloMinkowski

dimensotildees

7

8

9

10

11

12

espaccedilo G 4-

infor-maccedilatildeo

a consciecircncia do indiviacuteduo entra em

contato com a consciecircncia coacutesmica

eventos no mundomaterial

(colapso da

onda de probabilidade)

Kosyrev-space

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

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Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

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Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

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Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

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Autor Arnoldo de Souza 51

101

102

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Autor Arnoldo de Souza 52

103

104

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Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

107

108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 20: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 20

39

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Campos potenciais estruturam o espaccedilo

40

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria

Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido

para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 21: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 21

41

as ceacutelulas satildeo unidades funcionais autocircnomas

elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores

42

O sistema baacutesico de regulaccedilatildeo

silicea a qual se fixa geometricamente

aosPGGAGs

(nanospacer)

estrutura baacutesica da matrix (segundo HHeine)

Aacutegua cristalina Eacute armazenada entre

os PGGAGs

Proteo-Glicos-aminoglicanos

Silicea determina a geometria da matrix

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 22: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 22

43

O QUE Eacute A DOENCcedilA

a) Transtorno na simbiose b) Defeito na Barreira muco

intestinalc) Deacuteficit imunoloacutegico nas placas de

Peyerd) Intoxicaccedilatildeo sistecircmica

e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio

44

ldquoReserva de O2rdquo

ldquo Potencial de O2 fixado no tecidordquo

ldquoA presenccedila de O2 fixado no tecido permite ao sistema

imunoloacutegico o desdobramento imediato de sua defesa local

onde quer que seja requerida pois essa defesa soacute funciona

bem num ambiente rico em O2

Assim o potencial de O2 armazenado no organismo

assume a funccedilatildeo de um muro protetor que impede a

irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo

sauacutede a reserva de O2 fixada no tecidordquo

Hans-Georg Eberhardt -- Revision und Reform der Medizin

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

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Autor Arnoldo de Souza 37

73

74

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75

76

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77

78

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79

80

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81

82

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83

84

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85

86

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87

88

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89

90

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91

92

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93

94

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95

96

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97

98

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99

100

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101

102

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103

104

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105

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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121

122

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123

124

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125

126

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Autor Arnoldo de Souza 64

127

Page 23: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 23

45

ONDE OCORRE A DOENCcedilA

a) Intestino b) Substacircncia baacutesicaMatrix

c) Ceacutelula

46

capillary

with

erythrocyte

fibro-

blast

The cell matrix system

organ-

cells

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

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Autor Arnoldo de Souza 37

73

74

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75

76

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77

78

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Autor Arnoldo de Souza 40

79

80

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Autor Arnoldo de Souza 41

81

82

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Autor Arnoldo de Souza 42

83

84

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Autor Arnoldo de Souza 43

85

86

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Autor Arnoldo de Souza 44

87

88

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Autor Arnoldo de Souza 45

89

90

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Autor Arnoldo de Souza 46

91

92

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Autor Arnoldo de Souza 47

93

94

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Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

97

98

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Autor Arnoldo de Souza 50

99

100

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Autor Arnoldo de Souza 51

101

102

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Autor Arnoldo de Souza 52

103

104

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Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

107

108

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Autor Arnoldo de Souza 55

109

110

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 24: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 24

47

A estrutura dosPGGAGs silica eacute

fixa o que determina a geometria

(nanoespaccedilo)

Proteo-Glicosaminoglicanos Entre os

PGGAGsnoacutes encontramos aacutegua

cristalina

Silica determina a geometria da matrix

Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido

Aacutecido hialurocircnico

Bases Biofiacutesicas da Ozonioterapia

48

ESchroedinger (Quantumphysics bearer of Nobel award)

bdquoSistemas bioloacutegicos satildeo sistemas

coerentesldquo

bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo

bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 25: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 25

49

EFEITOS BIOLOacuteGICOS DO OZOcircNIO

MODULA O ESTRESSE

OXIDATIVO BIOLOacuteGICO

MELHORA O INFLUI NA

METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO

DEL OXIGEcircNIO DE EICOSANOacuteIDES

MODULADOR REGULADOR

IMUNOLOacuteGICO METABOacuteLICO

GERMICIDA DE

AMPLO ESPECTRO

Bases Biofiacutesicas da Ozonioterapia

50

Modulador do Stress oxidativo bioloacutegico

Bases Biofiacutesicas da Ozonioterapia

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

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70

Adelir Augusto Sesconete

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72

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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121

122

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127

Page 26: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 26

51

Bases Biofiacutesicas da Ozonioterapia

As 4 colunas da Ozonioterapia

Regulaccedilatildeo doMetabolismo

Avaliaccedilatildeo do niacutevel da patologia a ser tratada

Prevenccedilatildeo aos efeitos colaterais

Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo

52

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico

celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e

tambeacutem nas agudas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

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Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

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Autor Arnoldo de Souza 37

73

74

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Autor Arnoldo de Souza 38

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76

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Autor Arnoldo de Souza 39

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78

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Autor Arnoldo de Souza 40

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80

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Autor Arnoldo de Souza 41

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82

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Autor Arnoldo de Souza 42

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84

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Autor Arnoldo de Souza 43

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86

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Autor Arnoldo de Souza 44

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88

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Autor Arnoldo de Souza 45

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90

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Autor Arnoldo de Souza 46

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92

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Autor Arnoldo de Souza 47

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94

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Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

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98

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Autor Arnoldo de Souza 50

99

100

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Autor Arnoldo de Souza 51

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102

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Autor Arnoldo de Souza 52

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Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

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108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 27

53

Bases biofiacutesicas da Ozonioterapia

A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo

54

Bases Biofiacutesicas da Ozonioterapia

Como funciona a Ozonioterapia

Existe uma alteraccedilao do fluxo eleacutetrico

desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular

celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel

da matrix e da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

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Autor Arnoldo de Souza 37

73

74

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Autor Arnoldo de Souza 38

75

76

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Autor Arnoldo de Souza 39

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78

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Autor Arnoldo de Souza 40

79

80

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Autor Arnoldo de Souza 41

81

82

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Autor Arnoldo de Souza 42

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84

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Autor Arnoldo de Souza 43

85

86

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Autor Arnoldo de Souza 44

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88

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Autor Arnoldo de Souza 45

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90

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Autor Arnoldo de Souza 46

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92

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Autor Arnoldo de Souza 47

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94

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Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

97

98

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Autor Arnoldo de Souza 50

99

100

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Autor Arnoldo de Souza 51

101

102

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Autor Arnoldo de Souza 52

103

104

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Autor Arnoldo de Souza 53

105

106

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Autor Arnoldo de Souza 54

107

108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 28: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 28

55

Bases biofiacutesicas daOzonioterapia

Como isto funciona

O sistema nervoso simpaacutetico e o

parassimpaacutetico sofrem

modificaccediloes causadas por O2 +

O3

56

Bases biofiacutesicas da Ozonioterapia

O oxigecircnio tem uma

frequecircncia de absorccedilao de

400 nm ateacute 475nm

075 x 1015 Hz frequencia do

infravermelho da luz visiacutevel

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

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Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

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Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 29

57

As pontes de

hidrogecircnio vibram na

frequumlencia de 95

1013 =frequumlecircncia das

micro ondas

Apresentam valecircncias

interatocircmicas no

espectro da frequumlecircncia

do infravermelho

Bases biofiacutesicas da Ozonioterapia

58

BASES BIOFIacuteSICAS DAOZONIOTERAPIA

As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no

niacutevel teacutecnico ao laser de Helio-Neon

bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

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Autor Arnoldo de Souza 37

73

74

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Autor Arnoldo de Souza 38

75

76

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Autor Arnoldo de Souza 39

77

78

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Autor Arnoldo de Souza 40

79

80

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Autor Arnoldo de Souza 41

81

82

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Autor Arnoldo de Souza 42

83

84

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Autor Arnoldo de Souza 43

85

86

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Autor Arnoldo de Souza 44

87

88

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Autor Arnoldo de Souza 45

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90

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Autor Arnoldo de Souza 46

91

92

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Autor Arnoldo de Souza 47

93

94

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Autor Arnoldo de Souza 48

95

96

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Autor Arnoldo de Souza 49

97

98

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Autor Arnoldo de Souza 50

99

100

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Autor Arnoldo de Souza 51

101

102

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Autor Arnoldo de Souza 52

103

104

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Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 30: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 30

59

bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o

bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)

bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente

bull Mateacuteria morta-equiliacutebrio termodinacircmico

bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica

Bases Biofiacutesicas da Ozonioterapia

60

BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica

a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan

dos corpuacutesculos de Meissner das placas de Peyer

dos baroreceptores e tambeacutem nas estruturas da

matriz em torno da membrana celular

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

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Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 31

61

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Portanto 1- modula o sistema

neurovegetativo2- reverte o desvio

metaboacutelico3-estimula a renovaccedilatildeo e

siacutentese da matrix extracelularrenovando os

tecidos e acentuando a siacutentese do colaacutegeno e a

neo vascularizaccedilao tecidual

62

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees

O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas

A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso

central ao perifeacuterico

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

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Autor Arnoldo de Souza 39

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78

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Autor Arnoldo de Souza 40

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80

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Autor Arnoldo de Souza 41

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82

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Autor Arnoldo de Souza 42

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84

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Autor Arnoldo de Souza 43

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86

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Autor Arnoldo de Souza 44

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88

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Autor Arnoldo de Souza 45

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90

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Autor Arnoldo de Souza 46

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Autor Arnoldo de Souza 47

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94

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Autor Arnoldo de Souza 48

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96

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Autor Arnoldo de Souza 49

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98

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Autor Arnoldo de Souza 50

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100

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Autor Arnoldo de Souza 51

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102

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Autor Arnoldo de Souza 52

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104

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Autor Arnoldo de Souza 53

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106

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Autor Arnoldo de Souza 54

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108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 32: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 32

63

BASES BIOFIacuteSICAS DA OZONIOTERAPIA

Quadro Resumo

Regeneraccedilatildeo

tecidual

Ozonioterapia

O3

Receptoresteciduais

Equiliacutebrio do metabolismo

SN neuro vegetativoSN central

pressatildeo

64

OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA

Rokitansky AacuteustriaMatassi MilatildeoItaacutelia

RomeroCubaPoloniaHolanda De Monte Van der Zee

Lo PretteKraft( HAS)

BocciSiena ItaacuteliaDi Paolo Itaacuteli

Zhulina RuacutessiaHernandezCuba

Patterson amp RungeWasser

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

75

76

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 39

77

78

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 40

79

80

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

81

82

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 42

83

84

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 43

85

86

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

87

88

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 45

89

90

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 46

91

92

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 47

93

94

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 48

95

96

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 49

97

98

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

99

100

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 33: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 33

65

EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees

VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920

sessotildeesHidroozocircnio 420 pacientes com

9640sessotildeesTotal 1838 pacientes com 32402

sessotildees

66

OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM

CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo

Coronariopatias Distuacuterbios metaboacutelicos

Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

68

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

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Autor Arnoldo de Souza 37

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

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Autor Arnoldo de Souza 63

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126

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Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 34

67

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Autor Arnoldo de Souza 35

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Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

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72

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Autor Arnoldo de Souza 51

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Autor Arnoldo de Souza 52

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 35: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 35

69

70

Adelir Augusto Sesconete

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 36

71

72

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 37

73

74

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Autor Arnoldo de Souza 38

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Autor Arnoldo de Souza 39

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Autor Arnoldo de Souza 43

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Autor Arnoldo de Souza 50

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Autor Arnoldo de Souza 51

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Autor Arnoldo de Souza 52

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

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Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

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Autor Arnoldo de Souza 63

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Autor Arnoldo de Souza 64

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21O Curso de Ozonioterapia 9242016

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Autor Arnoldo de Souza 55

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 38

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Autor Arnoldo de Souza 42

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Autor Arnoldo de Souza 43

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Autor Arnoldo de Souza 51

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Autor Arnoldo de Souza 52

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Autor Arnoldo de Souza 53

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106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

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Autor Arnoldo de Souza 64

127

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Autor Arnoldo de Souza 55

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 41

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Autor Arnoldo de Souza 42

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Autor Arnoldo de Souza 48

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Autor Arnoldo de Souza 49

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Autor Arnoldo de Souza 50

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Autor Arnoldo de Souza 51

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Autor Arnoldo de Souza 53

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Autor Arnoldo de Souza 54

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108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

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Autor Arnoldo de Souza 64

127

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

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Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

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Autor Arnoldo de Souza 55

109

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 44

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Autor Arnoldo de Souza 52

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Autor Arnoldo de Souza 53

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Autor Arnoldo de Souza 54

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

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Autor Arnoldo de Souza 53

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Autor Arnoldo de Souza 55

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110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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Autor Arnoldo de Souza 61

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Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

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Autor Arnoldo de Souza 52

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Autor Arnoldo de Souza 53

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108

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

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Autor Arnoldo de Souza 55

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110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

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21O Curso de Ozonioterapia 9242016

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Autor Arnoldo de Souza 55

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110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 64

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 50

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Autor Arnoldo de Souza 54

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Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 51

101

102

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

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Autor Arnoldo de Souza 53

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106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 52: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 52

103

104

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 53

105

106

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 54

107

108

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 55: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 55

109

110

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 63

125

126

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 64

127

Page 56: OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO ERITROCITÁRIO Aumento do 2,3 Difosfoglicerato e 6 GPDH Aumento da Oxigenação Tecidual

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 56

111

Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23

[The effect of ozone therapy on the activity of the autonomic nervous

system]

[Article in Russian]

Kuzmina VIu Khokhlov IuK Savin AA

Abstract

We studied 48 patients mean age 57 years 14 men 34 women with

chronic cerebrovascular disease and autonomic dysfunction Patients had

different types of autonomic response (sympathicotonic or normotonic)

Autonomic tone at baseline autonomic reactivity and autonomic supply of

activity were determined Patients were divided into 2 groups Patients of

the main group received ozone therapy along with standard medications

Patients of the control group received standard medications Disturbances

of vascular-autonomic regulation with the domination of ergotropic

sympathetic effects were identified in 697 of patients with chronic

cerebrovascular disease Ozone therapy caused a shift of the autonomic

balance towards the parasympathetic activity as well as the decrease in the

activity of the vasomotor center and the central regulation circuit that

indicates the increase in the power of defense mechanisms associated with

the normalization of autonomic balance

PMID 23250592 [PubMed - indexed for MEDLINE]

112

Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85

May oxygen-ozone therapy improves cardiovascular disorders

Bocci V Travagli V Zanardi I

Source

Department of Physiology University of Siena Via Aldo Moro 2

53100 Siena Italy bocciunisiit

Abstract

In an aging population vascular disorders well exemplified by the

chronic limb ischemia chronic heart failure cerebral ischemia and

age-related macular degeneration represent a serious medical and

socio-economical problem While there is always a not easily

identifiable first pathogenic noxa all of these diseases are

characterized by ischemia chronic inflammation and tissue

degeneration Orthodox medicine has provided several optimal drugs

targeting various pathological situations but even with their

concomitant applications it is not possible to reduce the chronic

oxidative stress Here it is proposed to associate the approach of

ozonated autohemotherapy as a modifier of the biological response

capable to block the pathological progress

PMID 19519366 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

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Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 57

113

Voen Med Zh 2009 Aug330(8)30-2

[A complex medical rehabilitation of patients with coronary

heart disease underwent coronary shunting using air-ozone

baths]

[Article in Russian]

Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV

Abstract

Ozone therapeutics is one of not medicated methods of treatment of

coronary heart disease (CHD) For external application of ozone

therapeutics was elaborated an air-ozone bath Endurance of

procedure is 20 minutes ozone concentration is 8-10 mgl in

ozonized water and temperature of air-ozone mix is 36 degrees C

Course of treatment consisted of 10 daily procedures Searches are

founded on the base of analyze of results of remedial treatment of

160 patients with CHD Patient--men aged from 41 to 65 years

(average age is 556 +- 56) 130 patients of them underwent an

operation of coronary shunting (CS) admitted to unit on 7-18th day

after operation (in average--on 144 +- 36th) and 30 patients

without operational treatment Program of patient observe consisted

of general-clinical laboratorial functional and psychological

methods of searches It was established that using of air-ozone bath

in complex program of rehabilitation of patients with CHD after

operation of CS promotes to improvement of oxygen transporting

flow characteristics of blood microcirculation lowering of hypoxemia

and hypoxia of tissue

PMID 19916311 [PubMed - indexed for MEDLINE]

Publication Types MeSH Terms Substances

114

Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009

Sep 10

Oxygen-ozone therapy in medicine an update

Bocci V Di Paolo N

Source

Department of Physiology University of Siena Siena Italy

bocciunisiit

Abstract

Oxygen-ozone therapy initially started as an empirical approach

has now reached a stage where most of the biological mechanisms

of action of ozone have been clarified showing that they are in the

realm of orthodox biochemistry physiology and pharmacology Here

we have reviewed a few relevant clinical applications and have

shown that ozone therapy is particularly useful in cardiovascular

disorders and tissue ischemia In chronic viral infections it is unable

to eliminate the viremia but it may display supportive help by

stimulating the immune system Recently its use has been

successfully extended to the herniated disk pathology and therapy of

primary caries in children

Copyright 2009 S Karger AG Basel

PMID 19752547 [PubMed - indexed for MEDLINE]

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

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127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 58

115

Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036

Preconditioning with ozone abrogates acute rejection and prolongs cardiac

allograft survival in rats

Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S

Source

Department of Internal Medicine Division of Cardiology Justus-Liebig-University

Giessen Germany ThomasStadlbauergmxde

Abstract

Acute cardiac allograft rejection remains a major cause of morbidity and mortality after

heart transplantation and predisposes for the development of graft vasculopathy The

aim of this study was to investigate the immunomodulatory effect of preconditioning of

the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection

Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft

vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis

rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals

a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or

repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of

medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac

allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single

bolus as well as repetitive administration n = 7) of the donor and recipient animals

prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without

any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal

administration of ozone in donor and recipient animals protected from ischemia-

reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac

allograft survival Further studies are warranted to elucidate the underlying

mechanisms and--more important--to investigate the effect on the development of graft

vasculopathy the major obstacle to long-term graft and patient survivals

PMID 18555093 [PubMed - indexed for MEDLINE]

116

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 62

123

124

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Autor Arnoldo de Souza 63

125

126

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127

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21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 59

117

118

OZONIOTERAPIA EM CARDIOLOGIA

Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem

Franccedilois TruffautObrigado

Arnoldo de Souza arnoldoscardiolbr

Arnoldo de Souza arnoldoscardiolbr

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 60

119

120

21O Curso de Ozonioterapia 9242016

Autor Arnoldo de Souza 61

121

122

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Autor Arnoldo de Souza 62

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Autor Arnoldo de Souza 61

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