OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO...
Transcript of OZONIOTERAPIA EM CARDIOLOGIA · 2020. 11. 13. · OZONIO : EFEITOS BIOLÓGICOS DO USO DO OZÔNIO...
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 1
Dr Arnoldo de Souza OZONIOTERAPIA EM CARDIOLOGIA
2
OZONIOTERAPIA EM CARDIOLOGIA
OxigecircnioOzonioterapia
pode melhorar doenccedilas cardiovasculares
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Autor Arnoldo de Souza 2
3
OZONIOTERAPIA EM CARDIOLOGIA
Envelhecimento Populacional
Isquemia crocircnica
Ins Cardiacuteaca Crocircnica
Isquemia cerebral
Degeneraccedilatildeo Macular
4
SIMPATICOTONIA STRESS
Aterosclerose
Teorias SNS elevado Stress Fumo Poluiccedilatildeo
Dieta rica em CH
As comorbidades tb cursam com SNS elevado
DMHAS Apneacuteia do sono Disfunccedilatildeo ereacutetil
Aumento de aacutec laacutetico =Aumento de lipiacutedios
intracoronaacuterios
Lacto acidoseAterosclerose
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Autor Arnoldo de Souza 3
5
ATEROSCLEROSE TEORIAS
Jurgen
Trecircs compartimentos
Matriz extracelular
Reserva de O2
Metabolismo
PH
SNA
6
ATEROSCLEROSE TEORIAS
Inflamaccedilatildeo
Isquemia crocircnica
Degeneraccedilatildeo tecidual
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7
BASIC REGULATION OF THE CELL-METABOLISM
synthesis metabolism
energymetabolism
anabolic cataboliccortisol thyroxin(catabolic effect)
HGH anabpeptids(anabolic effect)
SHOCK STRESSunstabile regulatory equilibrium
= state of metabolism = anabolic derailment catabolic derailment
8
Equiliacutebrio Instaacutevel
bullA regulaccedilatildeo do metabolismo celular
soacute eacute possiacutevel quando e se todos os
3 reguladores o anaboacutelico HGH (
hormocircnio do crescimento) bem
como os 2 hormocircnios cataboacutelicos
cortisol + tiroxina estatildeo presentes
na ceacutelula em seu iacutentimo e juntos ao
mesmo tempo (atJSchole)
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Autor Arnoldo de Souza 5
9
Equiliacutebrio Instaacutevel
O atual
estado do metabolismo
reflete o
potential redox
10
Equiliacutebrio Instaacutevel
bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica
bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)
bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox
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Autor Arnoldo de Souza 6
11
Desvio Anaboacutelico significa
- baixa velocidade de siacutentese(energia )
- divisatildeo celular tardia ceacutel grande
- epi e endoteacutelio tornam-se espessos
- resultado cel grande e sem funccedilatildeo
- oxidaccedilatildeo e hidroacutelise diminuem
12
OZONIOTERAPIA EM CARDIOLOGIA
Desvio cataboacutelico significa
-
- oxidaccedilatildeo e aumento de radicais
livres
- divisatildeo celular prematura
- epiteacutelio e endoteacutelio mais finos
- resultado celulaspequenas sem
funccedilatildeo adequada
- oxidaccedilatildeo e hidrolise se elevam
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13
OZONIOTERAPIA EM CARDIOLOGIA
Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares
Inflamaccedilatildeo
Isquemia
14
MECANISMO DE ACcedilAtildeO DO OZOcircNIO
O3
P
L
A
SM
A
ROS
( H2O2)
LOPs
ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2
LINFOacuteCITOS Ativaccedilatildeo da Imunidade
PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento
Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico
MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco
Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular
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15
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO
Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria
16
O AUMENTO DA VELOCIDADE DA
GLICOacuteLISE NO ERITROacuteCITO Eacute
ACOMPANHADO DE UM
SIGNIFICATIVO AUMENTO NO
INTERCAcircMBIO DE IacuteONS SOacuteDIO E
POTAacuteSSIO OS QUAIS SAtildeO
RESPONSAacuteVEIS POR MANTER O
POTENCIAL ELEacuteTRICO DE
MEMBRANA
ATIVA METABOLISMO DAS HEMAacuteCIAS
AS DOENCcedilAS ARTERIAIS OCLUSIVAS
ESTAtildeO RELACIONADAS COM A REDUCcedilAO
DO POTENCIAL DE MEMBRANA
A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS
PELO OZOcircNIO E SEUS PRODUTOS
FAVORECE A RESTAURACcedilAtildeO DO
POTENCIAL DE ACcedilAtildeO DA MEMBRANA
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17
MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL
MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA
FRAGMENTO DA
ANAacuteLISE DO SANGUE
DE UMA PESSOA
SAUDAacuteVEL E
MICROSCOacutePIO DIGITAL
HOLOGRAacuteFICO
INTERFEREcircNCIAL
18
TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL
Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov
ESQUEMA DE DETERMINACcedilAtildeO DO
COEFICIENTE DE ESFERICIDADE
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19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
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21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
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23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
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25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
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REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
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29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
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ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
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PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
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35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
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37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
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39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
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41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
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43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
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45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
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47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
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49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
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51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
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53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
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Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
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57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
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59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
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BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
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65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
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68
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70
Adelir Augusto Sesconete
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72
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76
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78
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80
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84
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88
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90
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100
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Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
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113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
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115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
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Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
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119
120
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122
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123
124
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125
126
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Autor Arnoldo de Souza 2
3
OZONIOTERAPIA EM CARDIOLOGIA
Envelhecimento Populacional
Isquemia crocircnica
Ins Cardiacuteaca Crocircnica
Isquemia cerebral
Degeneraccedilatildeo Macular
4
SIMPATICOTONIA STRESS
Aterosclerose
Teorias SNS elevado Stress Fumo Poluiccedilatildeo
Dieta rica em CH
As comorbidades tb cursam com SNS elevado
DMHAS Apneacuteia do sono Disfunccedilatildeo ereacutetil
Aumento de aacutec laacutetico =Aumento de lipiacutedios
intracoronaacuterios
Lacto acidoseAterosclerose
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 3
5
ATEROSCLEROSE TEORIAS
Jurgen
Trecircs compartimentos
Matriz extracelular
Reserva de O2
Metabolismo
PH
SNA
6
ATEROSCLEROSE TEORIAS
Inflamaccedilatildeo
Isquemia crocircnica
Degeneraccedilatildeo tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 4
7
BASIC REGULATION OF THE CELL-METABOLISM
synthesis metabolism
energymetabolism
anabolic cataboliccortisol thyroxin(catabolic effect)
HGH anabpeptids(anabolic effect)
SHOCK STRESSunstabile regulatory equilibrium
= state of metabolism = anabolic derailment catabolic derailment
8
Equiliacutebrio Instaacutevel
bullA regulaccedilatildeo do metabolismo celular
soacute eacute possiacutevel quando e se todos os
3 reguladores o anaboacutelico HGH (
hormocircnio do crescimento) bem
como os 2 hormocircnios cataboacutelicos
cortisol + tiroxina estatildeo presentes
na ceacutelula em seu iacutentimo e juntos ao
mesmo tempo (atJSchole)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 5
9
Equiliacutebrio Instaacutevel
O atual
estado do metabolismo
reflete o
potential redox
10
Equiliacutebrio Instaacutevel
bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica
bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)
bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 6
11
Desvio Anaboacutelico significa
- baixa velocidade de siacutentese(energia )
- divisatildeo celular tardia ceacutel grande
- epi e endoteacutelio tornam-se espessos
- resultado cel grande e sem funccedilatildeo
- oxidaccedilatildeo e hidroacutelise diminuem
12
OZONIOTERAPIA EM CARDIOLOGIA
Desvio cataboacutelico significa
-
- oxidaccedilatildeo e aumento de radicais
livres
- divisatildeo celular prematura
- epiteacutelio e endoteacutelio mais finos
- resultado celulaspequenas sem
funccedilatildeo adequada
- oxidaccedilatildeo e hidrolise se elevam
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 7
13
OZONIOTERAPIA EM CARDIOLOGIA
Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares
Inflamaccedilatildeo
Isquemia
14
MECANISMO DE ACcedilAtildeO DO OZOcircNIO
O3
P
L
A
SM
A
ROS
( H2O2)
LOPs
ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2
LINFOacuteCITOS Ativaccedilatildeo da Imunidade
PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento
Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico
MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco
Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 8
15
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO
Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria
16
O AUMENTO DA VELOCIDADE DA
GLICOacuteLISE NO ERITROacuteCITO Eacute
ACOMPANHADO DE UM
SIGNIFICATIVO AUMENTO NO
INTERCAcircMBIO DE IacuteONS SOacuteDIO E
POTAacuteSSIO OS QUAIS SAtildeO
RESPONSAacuteVEIS POR MANTER O
POTENCIAL ELEacuteTRICO DE
MEMBRANA
ATIVA METABOLISMO DAS HEMAacuteCIAS
AS DOENCcedilAS ARTERIAIS OCLUSIVAS
ESTAtildeO RELACIONADAS COM A REDUCcedilAO
DO POTENCIAL DE MEMBRANA
A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS
PELO OZOcircNIO E SEUS PRODUTOS
FAVORECE A RESTAURACcedilAtildeO DO
POTENCIAL DE ACcedilAtildeO DA MEMBRANA
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17
MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL
MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA
FRAGMENTO DA
ANAacuteLISE DO SANGUE
DE UMA PESSOA
SAUDAacuteVEL E
MICROSCOacutePIO DIGITAL
HOLOGRAacuteFICO
INTERFEREcircNCIAL
18
TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL
Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov
ESQUEMA DE DETERMINACcedilAtildeO DO
COEFICIENTE DE ESFERICIDADE
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19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
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21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
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23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
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25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
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Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
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29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
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31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
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69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
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71
72
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73
74
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75
76
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77
78
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79
80
21O Curso de Ozonioterapia 9242016
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81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
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85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
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89
90
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91
92
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93
94
21O Curso de Ozonioterapia 9242016
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95
96
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97
98
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99
100
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101
102
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103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
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107
108
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109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 3
5
ATEROSCLEROSE TEORIAS
Jurgen
Trecircs compartimentos
Matriz extracelular
Reserva de O2
Metabolismo
PH
SNA
6
ATEROSCLEROSE TEORIAS
Inflamaccedilatildeo
Isquemia crocircnica
Degeneraccedilatildeo tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 4
7
BASIC REGULATION OF THE CELL-METABOLISM
synthesis metabolism
energymetabolism
anabolic cataboliccortisol thyroxin(catabolic effect)
HGH anabpeptids(anabolic effect)
SHOCK STRESSunstabile regulatory equilibrium
= state of metabolism = anabolic derailment catabolic derailment
8
Equiliacutebrio Instaacutevel
bullA regulaccedilatildeo do metabolismo celular
soacute eacute possiacutevel quando e se todos os
3 reguladores o anaboacutelico HGH (
hormocircnio do crescimento) bem
como os 2 hormocircnios cataboacutelicos
cortisol + tiroxina estatildeo presentes
na ceacutelula em seu iacutentimo e juntos ao
mesmo tempo (atJSchole)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 5
9
Equiliacutebrio Instaacutevel
O atual
estado do metabolismo
reflete o
potential redox
10
Equiliacutebrio Instaacutevel
bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica
bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)
bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 6
11
Desvio Anaboacutelico significa
- baixa velocidade de siacutentese(energia )
- divisatildeo celular tardia ceacutel grande
- epi e endoteacutelio tornam-se espessos
- resultado cel grande e sem funccedilatildeo
- oxidaccedilatildeo e hidroacutelise diminuem
12
OZONIOTERAPIA EM CARDIOLOGIA
Desvio cataboacutelico significa
-
- oxidaccedilatildeo e aumento de radicais
livres
- divisatildeo celular prematura
- epiteacutelio e endoteacutelio mais finos
- resultado celulaspequenas sem
funccedilatildeo adequada
- oxidaccedilatildeo e hidrolise se elevam
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 7
13
OZONIOTERAPIA EM CARDIOLOGIA
Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares
Inflamaccedilatildeo
Isquemia
14
MECANISMO DE ACcedilAtildeO DO OZOcircNIO
O3
P
L
A
SM
A
ROS
( H2O2)
LOPs
ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2
LINFOacuteCITOS Ativaccedilatildeo da Imunidade
PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento
Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico
MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco
Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 8
15
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO
Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria
16
O AUMENTO DA VELOCIDADE DA
GLICOacuteLISE NO ERITROacuteCITO Eacute
ACOMPANHADO DE UM
SIGNIFICATIVO AUMENTO NO
INTERCAcircMBIO DE IacuteONS SOacuteDIO E
POTAacuteSSIO OS QUAIS SAtildeO
RESPONSAacuteVEIS POR MANTER O
POTENCIAL ELEacuteTRICO DE
MEMBRANA
ATIVA METABOLISMO DAS HEMAacuteCIAS
AS DOENCcedilAS ARTERIAIS OCLUSIVAS
ESTAtildeO RELACIONADAS COM A REDUCcedilAO
DO POTENCIAL DE MEMBRANA
A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS
PELO OZOcircNIO E SEUS PRODUTOS
FAVORECE A RESTAURACcedilAtildeO DO
POTENCIAL DE ACcedilAtildeO DA MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 9
17
MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL
MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA
FRAGMENTO DA
ANAacuteLISE DO SANGUE
DE UMA PESSOA
SAUDAacuteVEL E
MICROSCOacutePIO DIGITAL
HOLOGRAacuteFICO
INTERFEREcircNCIAL
18
TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL
Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov
ESQUEMA DE DETERMINACcedilAtildeO DO
COEFICIENTE DE ESFERICIDADE
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 10
19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 11
21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 12
23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 4
7
BASIC REGULATION OF THE CELL-METABOLISM
synthesis metabolism
energymetabolism
anabolic cataboliccortisol thyroxin(catabolic effect)
HGH anabpeptids(anabolic effect)
SHOCK STRESSunstabile regulatory equilibrium
= state of metabolism = anabolic derailment catabolic derailment
8
Equiliacutebrio Instaacutevel
bullA regulaccedilatildeo do metabolismo celular
soacute eacute possiacutevel quando e se todos os
3 reguladores o anaboacutelico HGH (
hormocircnio do crescimento) bem
como os 2 hormocircnios cataboacutelicos
cortisol + tiroxina estatildeo presentes
na ceacutelula em seu iacutentimo e juntos ao
mesmo tempo (atJSchole)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 5
9
Equiliacutebrio Instaacutevel
O atual
estado do metabolismo
reflete o
potential redox
10
Equiliacutebrio Instaacutevel
bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica
bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)
bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 6
11
Desvio Anaboacutelico significa
- baixa velocidade de siacutentese(energia )
- divisatildeo celular tardia ceacutel grande
- epi e endoteacutelio tornam-se espessos
- resultado cel grande e sem funccedilatildeo
- oxidaccedilatildeo e hidroacutelise diminuem
12
OZONIOTERAPIA EM CARDIOLOGIA
Desvio cataboacutelico significa
-
- oxidaccedilatildeo e aumento de radicais
livres
- divisatildeo celular prematura
- epiteacutelio e endoteacutelio mais finos
- resultado celulaspequenas sem
funccedilatildeo adequada
- oxidaccedilatildeo e hidrolise se elevam
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 7
13
OZONIOTERAPIA EM CARDIOLOGIA
Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares
Inflamaccedilatildeo
Isquemia
14
MECANISMO DE ACcedilAtildeO DO OZOcircNIO
O3
P
L
A
SM
A
ROS
( H2O2)
LOPs
ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2
LINFOacuteCITOS Ativaccedilatildeo da Imunidade
PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento
Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico
MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco
Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 8
15
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO
Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria
16
O AUMENTO DA VELOCIDADE DA
GLICOacuteLISE NO ERITROacuteCITO Eacute
ACOMPANHADO DE UM
SIGNIFICATIVO AUMENTO NO
INTERCAcircMBIO DE IacuteONS SOacuteDIO E
POTAacuteSSIO OS QUAIS SAtildeO
RESPONSAacuteVEIS POR MANTER O
POTENCIAL ELEacuteTRICO DE
MEMBRANA
ATIVA METABOLISMO DAS HEMAacuteCIAS
AS DOENCcedilAS ARTERIAIS OCLUSIVAS
ESTAtildeO RELACIONADAS COM A REDUCcedilAO
DO POTENCIAL DE MEMBRANA
A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS
PELO OZOcircNIO E SEUS PRODUTOS
FAVORECE A RESTAURACcedilAtildeO DO
POTENCIAL DE ACcedilAtildeO DA MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 9
17
MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL
MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA
FRAGMENTO DA
ANAacuteLISE DO SANGUE
DE UMA PESSOA
SAUDAacuteVEL E
MICROSCOacutePIO DIGITAL
HOLOGRAacuteFICO
INTERFEREcircNCIAL
18
TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL
Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov
ESQUEMA DE DETERMINACcedilAtildeO DO
COEFICIENTE DE ESFERICIDADE
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 10
19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 11
21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 12
23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
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BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
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BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
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65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
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68
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70
Adelir Augusto Sesconete
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72
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80
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Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
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115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
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117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
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119
120
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121
122
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123
124
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125
126
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Autor Arnoldo de Souza 5
9
Equiliacutebrio Instaacutevel
O atual
estado do metabolismo
reflete o
potential redox
10
Equiliacutebrio Instaacutevel
bullO estado atual do metabolismo representa a relaccedilatildeo entre a atividade anaboacutelica e cataboacutelica
bullA atividade predominante resulta da reduccedilatildeo de poder do seu parceiro polar (anabolismo ou catabolismo)
bullA chave do estado atual do metabolismo somente pode ser definida pelo potencial redox
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 6
11
Desvio Anaboacutelico significa
- baixa velocidade de siacutentese(energia )
- divisatildeo celular tardia ceacutel grande
- epi e endoteacutelio tornam-se espessos
- resultado cel grande e sem funccedilatildeo
- oxidaccedilatildeo e hidroacutelise diminuem
12
OZONIOTERAPIA EM CARDIOLOGIA
Desvio cataboacutelico significa
-
- oxidaccedilatildeo e aumento de radicais
livres
- divisatildeo celular prematura
- epiteacutelio e endoteacutelio mais finos
- resultado celulaspequenas sem
funccedilatildeo adequada
- oxidaccedilatildeo e hidrolise se elevam
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 7
13
OZONIOTERAPIA EM CARDIOLOGIA
Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares
Inflamaccedilatildeo
Isquemia
14
MECANISMO DE ACcedilAtildeO DO OZOcircNIO
O3
P
L
A
SM
A
ROS
( H2O2)
LOPs
ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2
LINFOacuteCITOS Ativaccedilatildeo da Imunidade
PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento
Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico
MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco
Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 8
15
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO
Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria
16
O AUMENTO DA VELOCIDADE DA
GLICOacuteLISE NO ERITROacuteCITO Eacute
ACOMPANHADO DE UM
SIGNIFICATIVO AUMENTO NO
INTERCAcircMBIO DE IacuteONS SOacuteDIO E
POTAacuteSSIO OS QUAIS SAtildeO
RESPONSAacuteVEIS POR MANTER O
POTENCIAL ELEacuteTRICO DE
MEMBRANA
ATIVA METABOLISMO DAS HEMAacuteCIAS
AS DOENCcedilAS ARTERIAIS OCLUSIVAS
ESTAtildeO RELACIONADAS COM A REDUCcedilAO
DO POTENCIAL DE MEMBRANA
A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS
PELO OZOcircNIO E SEUS PRODUTOS
FAVORECE A RESTAURACcedilAtildeO DO
POTENCIAL DE ACcedilAtildeO DA MEMBRANA
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Autor Arnoldo de Souza 9
17
MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL
MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA
FRAGMENTO DA
ANAacuteLISE DO SANGUE
DE UMA PESSOA
SAUDAacuteVEL E
MICROSCOacutePIO DIGITAL
HOLOGRAacuteFICO
INTERFEREcircNCIAL
18
TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL
Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov
ESQUEMA DE DETERMINACcedilAtildeO DO
COEFICIENTE DE ESFERICIDADE
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19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
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21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
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23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
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25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
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27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
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29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
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31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
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33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
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69
70
Adelir Augusto Sesconete
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71
72
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73
74
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75
76
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77
78
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79
80
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81
82
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83
84
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85
86
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87
88
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89
90
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91
92
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93
94
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95
96
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97
98
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99
100
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101
102
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103
104
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105
106
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107
108
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109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
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121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 6
11
Desvio Anaboacutelico significa
- baixa velocidade de siacutentese(energia )
- divisatildeo celular tardia ceacutel grande
- epi e endoteacutelio tornam-se espessos
- resultado cel grande e sem funccedilatildeo
- oxidaccedilatildeo e hidroacutelise diminuem
12
OZONIOTERAPIA EM CARDIOLOGIA
Desvio cataboacutelico significa
-
- oxidaccedilatildeo e aumento de radicais
livres
- divisatildeo celular prematura
- epiteacutelio e endoteacutelio mais finos
- resultado celulaspequenas sem
funccedilatildeo adequada
- oxidaccedilatildeo e hidrolise se elevam
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 7
13
OZONIOTERAPIA EM CARDIOLOGIA
Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares
Inflamaccedilatildeo
Isquemia
14
MECANISMO DE ACcedilAtildeO DO OZOcircNIO
O3
P
L
A
SM
A
ROS
( H2O2)
LOPs
ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2
LINFOacuteCITOS Ativaccedilatildeo da Imunidade
PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento
Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico
MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco
Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 8
15
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO
Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria
16
O AUMENTO DA VELOCIDADE DA
GLICOacuteLISE NO ERITROacuteCITO Eacute
ACOMPANHADO DE UM
SIGNIFICATIVO AUMENTO NO
INTERCAcircMBIO DE IacuteONS SOacuteDIO E
POTAacuteSSIO OS QUAIS SAtildeO
RESPONSAacuteVEIS POR MANTER O
POTENCIAL ELEacuteTRICO DE
MEMBRANA
ATIVA METABOLISMO DAS HEMAacuteCIAS
AS DOENCcedilAS ARTERIAIS OCLUSIVAS
ESTAtildeO RELACIONADAS COM A REDUCcedilAO
DO POTENCIAL DE MEMBRANA
A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS
PELO OZOcircNIO E SEUS PRODUTOS
FAVORECE A RESTAURACcedilAtildeO DO
POTENCIAL DE ACcedilAtildeO DA MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 9
17
MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL
MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA
FRAGMENTO DA
ANAacuteLISE DO SANGUE
DE UMA PESSOA
SAUDAacuteVEL E
MICROSCOacutePIO DIGITAL
HOLOGRAacuteFICO
INTERFEREcircNCIAL
18
TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL
Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov
ESQUEMA DE DETERMINACcedilAtildeO DO
COEFICIENTE DE ESFERICIDADE
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 10
19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 11
21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 12
23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
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69
70
Adelir Augusto Sesconete
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71
72
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73
74
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75
76
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77
78
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79
80
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81
82
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83
84
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85
86
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87
88
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89
90
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91
92
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93
94
21O Curso de Ozonioterapia 9242016
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95
96
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97
98
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99
100
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101
102
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Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
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107
108
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Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 7
13
OZONIOTERAPIA EM CARDIOLOGIA
Portanto duas caracteriacutesticas acompanham as doenccedilas cardiovasculares
Inflamaccedilatildeo
Isquemia
14
MECANISMO DE ACcedilAtildeO DO OZOcircNIO
O3
P
L
A
SM
A
ROS
( H2O2)
LOPs
ERITROacuteCITOS Aumenta a liberaccedilatildeo de O2
LINFOacuteCITOS Ativaccedilatildeo da Imunidade
PLAQUETAS Liberaccedilatildeo dos Fatores de Crescimento
Aumenta a liberaccedilatildeo de Oacutexido Niacutetrico
MEDULA OacuteSSEA - Geraccedilatildeo de eritroacutecitos super diferenciadose mobilizaccedilatildeo de ceacutelulas tronco
Aumenta as enzimas antioxidantes e por consequumlecircncia a capacidade antioxidante intracelular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 8
15
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO
Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria
16
O AUMENTO DA VELOCIDADE DA
GLICOacuteLISE NO ERITROacuteCITO Eacute
ACOMPANHADO DE UM
SIGNIFICATIVO AUMENTO NO
INTERCAcircMBIO DE IacuteONS SOacuteDIO E
POTAacuteSSIO OS QUAIS SAtildeO
RESPONSAacuteVEIS POR MANTER O
POTENCIAL ELEacuteTRICO DE
MEMBRANA
ATIVA METABOLISMO DAS HEMAacuteCIAS
AS DOENCcedilAS ARTERIAIS OCLUSIVAS
ESTAtildeO RELACIONADAS COM A REDUCcedilAO
DO POTENCIAL DE MEMBRANA
A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS
PELO OZOcircNIO E SEUS PRODUTOS
FAVORECE A RESTAURACcedilAtildeO DO
POTENCIAL DE ACcedilAtildeO DA MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 9
17
MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL
MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA
FRAGMENTO DA
ANAacuteLISE DO SANGUE
DE UMA PESSOA
SAUDAacuteVEL E
MICROSCOacutePIO DIGITAL
HOLOGRAacuteFICO
INTERFEREcircNCIAL
18
TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL
Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov
ESQUEMA DE DETERMINACcedilAtildeO DO
COEFICIENTE DE ESFERICIDADE
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 10
19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 11
21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 12
23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 8
15
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZOcircNIOERITROCITAacuteRIO
Aumento do 23 Difosfoglicerato e 6 GPDH Aumento da Oxigenaccedilatildeo Tecidual com melhora da flexibilidade da membrana por aumento da carga eleacutetrica negativa evitando o fenocircmeno de Rouleauxtornando o eritroacutecito mais deformaacutevel menor agregaccedilatildeo plaquetaacuteria
16
O AUMENTO DA VELOCIDADE DA
GLICOacuteLISE NO ERITROacuteCITO Eacute
ACOMPANHADO DE UM
SIGNIFICATIVO AUMENTO NO
INTERCAcircMBIO DE IacuteONS SOacuteDIO E
POTAacuteSSIO OS QUAIS SAtildeO
RESPONSAacuteVEIS POR MANTER O
POTENCIAL ELEacuteTRICO DE
MEMBRANA
ATIVA METABOLISMO DAS HEMAacuteCIAS
AS DOENCcedilAS ARTERIAIS OCLUSIVAS
ESTAtildeO RELACIONADAS COM A REDUCcedilAO
DO POTENCIAL DE MEMBRANA
A NORMALIZACcedilAtildeO DA TROCA DE IacuteONS
PELO OZOcircNIO E SEUS PRODUTOS
FAVORECE A RESTAURACcedilAtildeO DO
POTENCIAL DE ACcedilAtildeO DA MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 9
17
MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL
MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA
FRAGMENTO DA
ANAacuteLISE DO SANGUE
DE UMA PESSOA
SAUDAacuteVEL E
MICROSCOacutePIO DIGITAL
HOLOGRAacuteFICO
INTERFEREcircNCIAL
18
TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL
Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov
ESQUEMA DE DETERMINACcedilAtildeO DO
COEFICIENTE DE ESFERICIDADE
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 10
19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 11
21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 12
23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
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63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
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69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
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71
72
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73
74
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75
76
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77
78
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79
80
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81
82
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83
84
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85
86
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87
88
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89
90
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92
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93
94
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95
96
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97
98
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Autor Arnoldo de Souza 50
99
100
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Autor Arnoldo de Souza 51
101
102
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Autor Arnoldo de Souza 52
103
104
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Autor Arnoldo de Souza 53
105
106
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Autor Arnoldo de Souza 54
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108
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Autor Arnoldo de Souza 55
109
110
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Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
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121
122
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123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 9
17
MEacuteTODO DE MICROSCOPIA DIGITAL HOLOGRAacuteFICA INTERFERENCIAL
MEacuteTODO SIMPLES E EXATO PARA DETERMINAR O ESTADO FUNCIONAL DAS MEMBRANAS DOS ERITROacuteCITOS E A INFLUENCIA DO OZOcircNIO NAS CONDICcedilOtildeES DE PRAacuteTICA CLIacuteNICA
FRAGMENTO DA
ANAacuteLISE DO SANGUE
DE UMA PESSOA
SAUDAacuteVEL E
MICROSCOacutePIO DIGITAL
HOLOGRAacuteFICO
INTERFEREcircNCIAL
18
TIPOS BAacuteSICOS DE ERITROacuteCITOS DEMONSTRADOS NA MICROSCOPIacuteA HOLOGRAacuteFICA INTERFERENCIAL
Estudo com amostra de 78 pessoasBarkhotkina T et al National Polytechnic University Medical Center Ukraine Kharkov
ESQUEMA DE DETERMINACcedilAtildeO DO
COEFICIENTE DE ESFERICIDADE
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 10
19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 11
21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 12
23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
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29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
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31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
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33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
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35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
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Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
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49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
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51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
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53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
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55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
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57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
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59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
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67
68
21O Curso de Ozonioterapia 9242016
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69
70
Adelir Augusto Sesconete
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71
72
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74
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75
76
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77
78
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79
80
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81
82
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83
84
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85
86
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87
88
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90
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92
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93
94
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95
96
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97
98
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99
100
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101
102
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103
104
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105
106
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107
108
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109
110
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111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
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119
120
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121
122
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123
124
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125
126
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127
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19
ERITROacuteCITOS DOS PACIENTES COM PATOLOGIA ANTES E DEPOIS DA OZONOTERAPIA
20
EFEITOS DO O3 NAS HEMAacuteCIAS ndash
Resumindo
MELHORA LIBERACcedilAtildeO DE OXIGEcircNIO TECIDUAL
FENOcircMENO ANTISLUDGING
(SEDIMENTACcedilAtildeO)
FLEXIBILIDADE DE MEMBRANA
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 11
21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 12
23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
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29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
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31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
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33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
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35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
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37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
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43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
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45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
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Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
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49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
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51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
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Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
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67
68
21O Curso de Ozonioterapia 9242016
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69
70
Adelir Augusto Sesconete
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71
72
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73
74
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75
76
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77
78
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79
80
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81
82
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83
84
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85
86
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87
88
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89
90
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91
92
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93
94
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95
96
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97
98
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99
100
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101
102
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103
104
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105
106
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107
108
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109
110
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Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
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121
122
21O Curso de Ozonioterapia 9242016
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123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 11
21
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
IMUNOLOacuteGICO
Liberaccedilatildeo de imunomoduladorescitocinasinterferon interleucinas fator de necrose tumoral
Aumento da atividade Modulaccedilatildeo da atividade FagocitaacuteriaInflamatoacuteria
22
CASCATA INFLAMATOacuteRIA
bullATIVACcedilAtildeO DAS CEacuteLULAS T DETERMINA REACcedilOtildeES INTRACELULARES
bullLINFOacuteCITOS E MACROacuteFAGOS SECRETAM CITOCINAS PROacute-INFLAMATOacuteRIAS
bullCITOCINAS INDUZEM RESPOSTAS CELULARES
Adaptado dos slides Prof Z Fahmy Cuba 2010
Rosenberg AE et al Robbins Pathologic Basis of Disease 19941213-1271
Goronzy JJ et al Primer on the Rheumatic Diseases 1997155-161
B Cell
T Cell
Macrophage
Pannus
Cartilage
TNF
IL-1
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 12
23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
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69
70
Adelir Augusto Sesconete
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71
72
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73
74
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75
76
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77
78
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79
80
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81
82
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83
84
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85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
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89
90
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91
92
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93
94
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95
96
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97
98
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99
100
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101
102
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103
104
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Autor Arnoldo de Souza 53
105
106
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107
108
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109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
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121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 12
23
ACcedilAtildeO DAS CITOCINAS
bullMEDIADORES DE FUNCcedilOtildeES CELULARES
bullINDUZEM PRODUCcedilAtildeO DE OUTRAS CITOCINAS
bullPODEM REDUZIR A INFLAMACcedilAtildeO LIGANDO RECEPTORES CELULARES OU PREVENINDO A ATIVACcedilAtildeO CELULAR
Adaptado dos slides Prof Z Fahmy Cuba 2010
Arend WP et al Textbook of Rheumatology1993 227-247
Baumgartner SW et al South Med J 200093753-759
Moreland LW Cleve Clin J Med199966367-374
TNF
IL-1
Cell-surface
TNF receptor
Soluble
TNF receptor
24
REDUZ A PRODUCcedilAtildeO MIOCAacuteRDICA DE CITOQUINAS
PROacute-INFLAMATOacuteRIAS
Plt001 vs air
Plt005 vs airDrsquoAmico M et al Inflamm res 2008 571ndash5
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
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35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
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39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
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69
70
Adelir Augusto Sesconete
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71
72
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73
74
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75
76
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77
78
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79
80
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81
82
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83
84
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85
86
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87
88
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89
90
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91
92
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93
94
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95
96
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97
98
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99
100
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101
102
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103
104
21O Curso de Ozonioterapia 9242016
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105
106
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107
108
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109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
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121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 13
25
O3 INIBE TNF-Α E AUMENTA
CEacuteLULAS ENDOTELIAIS
26
OZONIO EFEITOS BIOLOacuteGICOS DO USO DO OZONIO
METABOacuteLICO
bull Aumento do ciclo das pentosesmdashgtglicoacutelisemdashgtaumenta o uso da glicose pelas ceacutelulas liberando energia
bull Aumento da cisatildeo dos Aacutecidos Graxos ( efeito termogecircnico)
bull Ativaccedilatildeo das Enzimas Antioxidantes mdashgt Reduz Radicais Livres
bull Aumento da Formaccedilatildeo de ATPmdashgt eleva Acido Piruacutevico__gtReduz Dim Acido Laacutetico (Diminui Fadiga Muscular)
bull Aumento na produccedilatildeo e liberaccedilatildeo do ONmdashgt Eleva a Oferta de O2 com melhora da funccedilatildeo Mitocondrial ( respiraccedilatildeo celular) e Muscular
bull Ativaccedilatildeo da Fosfolipase C mdashgtRetira Ca da Cisterna sarcoplasmaacutetica com aumento do Ca Intracelular ativaccedilatildeo da Calmomodulina e modulaccedilatildeo da intensidade da contratilidade muscular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
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69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
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71
72
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73
74
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75
76
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77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
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Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
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91
92
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93
94
21O Curso de Ozonioterapia 9242016
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95
96
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Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
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Autor Arnoldo de Souza 51
101
102
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Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
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Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 14
27
REGULADOR DO METABOLISMO
OBSERVACcedilOtildeES PREacute-CLIacuteNICAS E CLIacuteNICAS REALIZADAS
MODULACcedilAtildeO DE INDICADORES INICIALMENTE PATOLOacuteGICOS A VALORES NORMAIS
INDICADORES GLICOSE CREATININA HEMOGLOBINA HEMATOacuteCRITO PROTEIacuteNAS TOTAIS COLESTEROL TRIGLICERIacuteDIOS LIPOPROTEIacuteNAS ENZIMAS HEPAacuteTICAS BILIRRUBINA AacuteCIDO UacuteRICO AacuteC LAacuteTICO ENTRE OUTRAS
(Leoacuten OS 1998 Al-Dalain SM 2005 Hernandez F 1995 Baeuerle PA 1994 Borrego A 2004 Gonzaleacutez R 2004 Martineacutez G 2005 Al-Dalain SM 2005 Candelaacuterio J2001 Peralta C 2000 Hernandez F 2005)
28
OZOcircNIO FATORES DE RISCO
bullREDUZ
COLESTEROL TOTAL LDL E TRIGLICERIacuteDIOS (HERNANDEZ 1995)
HOMOCISTEIacuteNA (SIMONETTI V 2006)
bullAUMENTA
HDL (BISETTI 1988)
NO 14-16 H DEPOIS DA GAET (BOCCI 1998)
EXPRESSAtildeO DA HEMOXIGENASE 1
LIBERACcedilAtildeO LOCAL VASODILATACcedilAtildeO (Otterbein 1999)
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
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69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
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71
72
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73
74
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75
76
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77
78
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79
80
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81
82
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83
84
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85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
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Autor Arnoldo de Souza 45
89
90
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91
92
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93
94
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95
96
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97
98
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99
100
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101
102
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Autor Arnoldo de Souza 52
103
104
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Autor Arnoldo de Souza 53
105
106
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107
108
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Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 15
29
PROPRIEDADES DO OZONIO
bull Bactericida
bull Fungicida
bull Virostaacutetico
bull Melhora a reaccedilatildeo imunoloacutegica
bull Melhora a reologia do sangue
bull Reduz o ldquo empilhamento em moedasrdquo das hemaacutecias
bull Melhora a oxigenaccedilatildeo dos tecidos
bull Aumento do pO2 arterial
bull Liberaccedilatildeo de hematopoietina
bull Aumenta a atividade antioxidante
30
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS NEURODEGENERATIVAS
ParkinsonAlzheimerWilsonDemecircncias Senis e VascularesELAGlaucoma Acircngulo AbertoHipoacusia BilateralMaculopatias
Accedilatildeo do Ozocircnio
Aumenta o fluxo cerebral Melhora o metabolismo Corrige o estresse oxidativo Induz a enzima Hemo - Oxigenase 1 ndash Potente antioxidante
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
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69
70
Adelir Augusto Sesconete
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71
72
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73
74
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75
76
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77
78
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79
80
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81
82
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83
84
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85
86
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Autor Arnoldo de Souza 44
87
88
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89
90
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91
92
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93
94
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95
96
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97
98
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99
100
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101
102
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103
104
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Autor Arnoldo de Souza 53
105
106
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107
108
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109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 16
31
ACcedilOtildeES DA OZONIOTERAPIA
DOENCcedilAS ISQUEcircMICAS
Isquemia de Membros Superiores e Inferiores Isquemia Cerebral Isquemia Cardiacuteaca Estase Venosa
Accedilatildeo do Ozocircnio
Aumenta o fluxo vascular para aacutereas isquecircmicas melhorando a perfusatildeo
Aumento da induccedilatildeo da NO sintetase ---gt Aumento do NO ---gt Vasodilataccedilatildeo
Aumento da mobilizaccedilatildeo de ceacutelulas tronco Neoangiogecircnese
Inibiccedilatildeo da agregaccedilatildeo plaquetaacuteria ( aumento do NO)
32
Eacute a reduccedilatildeo ouaboliccedilatildeo do suprimento
sanguumliacuteneo para o tecido com posterior restituiccedilatildeo adequada do fluxo sanguumliacuteneo
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
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Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
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Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 17
33
PRINCIPAIS CAUSAS Aterosclerose
Trombose
Tromboembolismo
Pode ocorrer secundariamente em Transplantes de OacutergatildeosAngioplastias Cirurgias de ldquo by-passrdquo coronariano
34
CORACcedilAtildeOA Reperfusatildeo do miocaacuterdio na
sequumlecircncia de uma isquemia reversiacutevel leva a uma prolongada depressatildeo da
funccedilatildeo contraacutetil que estaacute correlacionada com vaacuterias
anormalidades bioquiacutemicas ultraestruturais e vasculares
A administraccedilatildeo de SOD e Catalase natildeo somente atenuaram a formaccedilatildeo de
RL como elevaram o grau de recuperaccedilatildeo cardiacuteaca
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
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71
72
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73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
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77
78
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79
80
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Autor Arnoldo de Souza 41
81
82
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Autor Arnoldo de Souza 42
83
84
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Autor Arnoldo de Souza 43
85
86
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Autor Arnoldo de Souza 44
87
88
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89
90
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91
92
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93
94
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95
96
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97
98
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Autor Arnoldo de Souza 50
99
100
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Autor Arnoldo de Souza 51
101
102
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Autor Arnoldo de Souza 52
103
104
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Autor Arnoldo de Souza 53
105
106
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107
108
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109
110
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Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
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Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
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119
120
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121
122
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123
124
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125
126
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127
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Autor Arnoldo de Souza 18
35
Abordagens para eliminaccedilaotilde
dos RL na
IsquemiaReperfusatildeo Varredores de
RL O2macrbull
SOD
H2O2Catalase
Peroxidase
OHbull
ManitolDMSO
Inibidores da XO
Alopurinol
Quelantes de
Ferro
Deferoxamina
Inibidores leucocitaacuterios AdenosinaIbuprofeno
AO naturais α-Tocoferol CoQ10
DrogascardiovascularesCaptoprilDiltiazemβ-Bloqueadores
Precursores de GSH N-Acetilcisteiacutena
36
O3Preserva o equiliacutebrio
antioxidanteproacute-oxidante essencial para
a vida e estimula o sistema de defesa
antioxidante endoacutegeno
Previne o dano de arquitetura orgacircnica
induzido pela isquemia
Diminui a acidose laacutetica induzida pela
isquemia
Pode preservar ATP
Protege contra inflamaccedilatildeo induzida
pela isquemia evitando o recrutamento
e a ativaccedilatildeo de neutroacutefilos que geram
EROS e estimulam o dano tecidual
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
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Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
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Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
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Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
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Autor Arnoldo de Souza 49
97
98
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Autor Arnoldo de Souza 50
99
100
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Autor Arnoldo de Souza 51
101
102
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Autor Arnoldo de Souza 52
103
104
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Autor Arnoldo de Souza 53
105
106
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Autor Arnoldo de Souza 54
107
108
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Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
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Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
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119
120
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121
122
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123
124
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125
126
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127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 19
37
Bases biofiacutesicas da Ozonioterapia
Ao mesmo tempo vivemos em 2 espaccedilos
Espaccedilo de Minkowski
Espaccedilo Kosyrev
espaccedilocom
massae
energia
MATEacuteRIArealidadeexpliacutecita
1a-6a dimensotildees deBHeim
ESPIRITOinfor-maccedilatildeo
impliacutecita
7a-12a dimensatildeo deBHeim
38
Bases biofiacutesicas da
Ozonioterapia
SER Humano sendo como um processo coacutesmico
dimensotildees
1
2
3
4
5
6
espaccedilo 3-D-
tempo
possi-bilidades
reali-zaccedilatildeo
espaccediloMinkowski
dimensotildees
7
8
9
10
11
12
espaccedilo G 4-
infor-maccedilatildeo
a consciecircncia do indiviacuteduo entra em
contato com a consciecircncia coacutesmica
eventos no mundomaterial
(colapso da
onda de probabilidade)
Kosyrev-space
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
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Autor Arnoldo de Souza 39
77
78
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Autor Arnoldo de Souza 40
79
80
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Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
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Autor Arnoldo de Souza 46
91
92
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Autor Arnoldo de Souza 47
93
94
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Autor Arnoldo de Souza 48
95
96
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Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
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Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 20
39
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Campos potenciais estruturam o espaccedilo
40
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
campos potenciais determinam a condiccedilatildeo( qualidade da estrutura) da mateacuteria
Nenhum polo carregado pode existir soacute o oponente polar sempre estaraacute incluido
para un proacuteton carregado positivamente estaraacute designado um eleacutetron carregado negativamente
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 21
41
as ceacutelulas satildeo unidades funcionais autocircnomas
elas regulam seu fluxo de informaccedilatildeo por um estado bem individual dos receptores
42
O sistema baacutesico de regulaccedilatildeo
silicea a qual se fixa geometricamente
aosPGGAGs
(nanospacer)
estrutura baacutesica da matrix (segundo HHeine)
Aacutegua cristalina Eacute armazenada entre
os PGGAGs
Proteo-Glicos-aminoglicanos
Silicea determina a geometria da matrix
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
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Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 22
43
O QUE Eacute A DOENCcedilA
a) Transtorno na simbiose b) Defeito na Barreira muco
intestinalc) Deacuteficit imunoloacutegico nas placas de
Peyerd) Intoxicaccedilatildeo sistecircmica
e)Falta de substacircncias vitais ligada a um deacuteficit de oxigecircnio
44
ldquoReserva de O2rdquo
ldquo Potencial de O2 fixado no tecidordquo
ldquoA presenccedila de O2 fixado no tecido permite ao sistema
imunoloacutegico o desdobramento imediato de sua defesa local
onde quer que seja requerida pois essa defesa soacute funciona
bem num ambiente rico em O2
Assim o potencial de O2 armazenado no organismo
assume a funccedilatildeo de um muro protetor que impede a
irrupccedilatildeo da doenccedila ldquoPor isso eacute possiacutevel vincular o termo
sauacutede a reserva de O2 fixada no tecidordquo
Hans-Georg Eberhardt -- Revision und Reform der Medizin
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
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Autor Arnoldo de Souza 41
81
82
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Autor Arnoldo de Souza 42
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84
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Autor Arnoldo de Souza 43
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Autor Arnoldo de Souza 44
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Autor Arnoldo de Souza 45
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90
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Autor Arnoldo de Souza 46
91
92
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Autor Arnoldo de Souza 47
93
94
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Autor Arnoldo de Souza 48
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96
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Autor Arnoldo de Souza 49
97
98
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Autor Arnoldo de Souza 50
99
100
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Autor Arnoldo de Souza 51
101
102
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Autor Arnoldo de Souza 52
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104
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Autor Arnoldo de Souza 53
105
106
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Autor Arnoldo de Souza 54
107
108
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Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 23
45
ONDE OCORRE A DOENCcedilA
a) Intestino b) Substacircncia baacutesicaMatrix
c) Ceacutelula
46
capillary
with
erythrocyte
fibro-
blast
The cell matrix system
organ-
cells
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 24
47
A estrutura dosPGGAGs silica eacute
fixa o que determina a geometria
(nanoespaccedilo)
Proteo-Glicosaminoglicanos Entre os
PGGAGsnoacutes encontramos aacutegua
cristalina
Silica determina a geometria da matrix
Silica e aacutegua cristalizada fazem do organismo um gigante cristal liacutequido
Aacutecido hialurocircnico
Bases Biofiacutesicas da Ozonioterapia
48
ESchroedinger (Quantumphysics bearer of Nobel award)
bdquoSistemas bioloacutegicos satildeo sistemas
coerentesldquo
bdquoQuem natildeo pode conceber sistemas coerentes natildeo esta apto a entender os sistemas bioloacutegicosldquo
bdquoSistemas vivos estatildeo aptos a produzirem condicotildees coerentesldquo (Schroedinger)
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
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69
70
Adelir Augusto Sesconete
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72
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111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
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119
120
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121
122
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123
124
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125
126
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127
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Autor Arnoldo de Souza 25
49
EFEITOS BIOLOacuteGICOS DO OZOcircNIO
MODULA O ESTRESSE
OXIDATIVO BIOLOacuteGICO
MELHORA O INFLUI NA
METABOLISMO SIacuteNTESE E LIBERACcedilAtildeO
DEL OXIGEcircNIO DE EICOSANOacuteIDES
MODULADOR REGULADOR
IMUNOLOacuteGICO METABOacuteLICO
GERMICIDA DE
AMPLO ESPECTRO
Bases Biofiacutesicas da Ozonioterapia
50
Modulador do Stress oxidativo bioloacutegico
Bases Biofiacutesicas da Ozonioterapia
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
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Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
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Autor Arnoldo de Souza 36
71
72
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74
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101
102
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Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
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125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 26
51
Bases Biofiacutesicas da Ozonioterapia
As 4 colunas da Ozonioterapia
Regulaccedilatildeo doMetabolismo
Avaliaccedilatildeo do niacutevel da patologia a ser tratada
Prevenccedilatildeo aos efeitos colaterais
Regeneraccedilatildeo da Matrize modulaccedilatildeodo sistemaneurovegetativo
52
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Os corpuacutesculos taacutecteis e sensoriais promovem um equilibrio sensiacutevel ao nivel bio-eleacutetrico
celular regulando as funccedilotildees deprimidas pelos desvios do metabolismo nas enfermidades crocircnicas e
tambeacutem nas agudas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
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72
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Autor Arnoldo de Souza 37
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74
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Autor Arnoldo de Souza 38
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76
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Autor Arnoldo de Souza 39
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78
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Autor Arnoldo de Souza 40
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80
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Autor Arnoldo de Souza 41
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82
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Autor Arnoldo de Souza 42
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84
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Autor Arnoldo de Souza 43
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86
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Autor Arnoldo de Souza 44
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88
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Autor Arnoldo de Souza 45
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90
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94
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96
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98
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Autor Arnoldo de Souza 50
99
100
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Autor Arnoldo de Souza 51
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102
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Autor Arnoldo de Souza 52
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104
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Autor Arnoldo de Souza 53
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106
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Autor Arnoldo de Souza 54
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Autor Arnoldo de Souza 55
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Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 27
53
Bases biofiacutesicas da Ozonioterapia
A modulaccedilatildeo eacute feita atraveacutes do sistema nervoso autocircnomo
54
Bases Biofiacutesicas da Ozonioterapia
Como funciona a Ozonioterapia
Existe uma alteraccedilao do fluxo eleacutetrico
desde o niacutevel da matriz extracelular ateacute o niacutevel biomolecular
celularcausando uma modificaccedilatildeo do metabolismo ao niacutevel
da matrix e da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
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Autor Arnoldo de Souza 38
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76
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Autor Arnoldo de Souza 39
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78
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Autor Arnoldo de Souza 40
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80
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82
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Autor Arnoldo de Souza 42
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84
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Autor Arnoldo de Souza 43
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86
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Autor Arnoldo de Souza 44
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88
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Autor Arnoldo de Souza 45
89
90
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Autor Arnoldo de Souza 46
91
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Autor Arnoldo de Souza 47
93
94
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Autor Arnoldo de Souza 48
95
96
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Autor Arnoldo de Souza 49
97
98
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Autor Arnoldo de Souza 50
99
100
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Autor Arnoldo de Souza 51
101
102
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Autor Arnoldo de Souza 52
103
104
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Autor Arnoldo de Souza 53
105
106
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Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 28
55
Bases biofiacutesicas daOzonioterapia
Como isto funciona
O sistema nervoso simpaacutetico e o
parassimpaacutetico sofrem
modificaccediloes causadas por O2 +
O3
56
Bases biofiacutesicas da Ozonioterapia
O oxigecircnio tem uma
frequecircncia de absorccedilao de
400 nm ateacute 475nm
075 x 1015 Hz frequencia do
infravermelho da luz visiacutevel
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
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Autor Arnoldo de Souza 39
77
78
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Autor Arnoldo de Souza 40
79
80
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Autor Arnoldo de Souza 41
81
82
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Autor Arnoldo de Souza 42
83
84
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Autor Arnoldo de Souza 43
85
86
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Autor Arnoldo de Souza 44
87
88
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Autor Arnoldo de Souza 45
89
90
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Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 29
57
As pontes de
hidrogecircnio vibram na
frequumlencia de 95
1013 =frequumlecircncia das
micro ondas
Apresentam valecircncias
interatocircmicas no
espectro da frequumlecircncia
do infravermelho
Bases biofiacutesicas da Ozonioterapia
58
BASES BIOFIacuteSICAS DAOZONIOTERAPIA
As ceacutelulas sadias emitem uma emissatildeo fotocircnica coerente que se aproxima no
niacutevel teacutecnico ao laser de Helio-Neon
bull Trocas photonicas ativasbull Emissatildeo photonica coerentebull Semelhante a um bomba propulsorabull laser He Ne Laser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
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Autor Arnoldo de Souza 45
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Autor Arnoldo de Souza 47
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Autor Arnoldo de Souza 48
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Autor Arnoldo de Souza 51
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Autor Arnoldo de Souza 53
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Autor Arnoldo de Souza 54
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Autor Arnoldo de Souza 55
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21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
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Autor Arnoldo de Souza 62
123
124
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Autor Arnoldo de Souza 63
125
126
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Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 30
59
bull O corpo humano irradia alta intensidade debull biophotons num espectro de frequecircnciabull entre as bull micro o
bull ndas ( 10sup1sup2 ) e o infra vermelho ( 10sup1sup3 ) ( Bigu del Blanco)
bull Mateacuteria e bull Sistema Bioloacutegicos- Radiaccedilatildeo coerente e incoerente
bull Mateacuteria morta-equiliacutebrio termodinacircmico
bull Sistemas bioloacutegicos vivos instabilidade termodinacircmica
Bases Biofiacutesicas da Ozonioterapia
60
BASES BIOFIacuteSICAS DAOZONIOTERAPIAA mistura de O2+O3 modifica
a conduccedilatildeo bio-eleacutetrica ao niacutevel dos ductos de Bonghan
dos corpuacutesculos de Meissner das placas de Peyer
dos baroreceptores e tambeacutem nas estruturas da
matriz em torno da membrana celular
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
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Autor Arnoldo de Souza 38
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76
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Autor Arnoldo de Souza 39
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78
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Autor Arnoldo de Souza 40
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Autor Arnoldo de Souza 41
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82
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Autor Arnoldo de Souza 42
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84
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Autor Arnoldo de Souza 43
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Autor Arnoldo de Souza 44
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88
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Autor Arnoldo de Souza 45
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Autor Arnoldo de Souza 46
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Autor Arnoldo de Souza 47
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Autor Arnoldo de Souza 48
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Autor Arnoldo de Souza 49
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Autor Arnoldo de Souza 50
99
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Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 31
61
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Portanto 1- modula o sistema
neurovegetativo2- reverte o desvio
metaboacutelico3-estimula a renovaccedilatildeo e
siacutentese da matrix extracelularrenovando os
tecidos e acentuando a siacutentese do colaacutegeno e a
neo vascularizaccedilao tecidual
62
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
O2 + O3 fornecem o incremento energeacutetico para as modificaccedilotildees
O fluxo bioeleacutetrico tecidual eacute estimulado facilitando as trocas metaboacutelicas
A modulaccedilatildeo dos receptores ao niacutevel da pele intestinos endoteacutelio vascular e tecido conjuntivo acelera o fluxo de informaccedilatildeo desde o sistema nervoso
central ao perifeacuterico
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
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Autor Arnoldo de Souza 40
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80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
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82
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Autor Arnoldo de Souza 42
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84
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Autor Arnoldo de Souza 43
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Autor Arnoldo de Souza 44
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88
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Autor Arnoldo de Souza 45
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90
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Autor Arnoldo de Souza 46
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Autor Arnoldo de Souza 47
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Autor Arnoldo de Souza 48
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Autor Arnoldo de Souza 49
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Autor Arnoldo de Souza 50
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Autor Arnoldo de Souza 51
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21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
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21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
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21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
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21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 32
63
BASES BIOFIacuteSICAS DA OZONIOTERAPIA
Quadro Resumo
Regeneraccedilatildeo
tecidual
Ozonioterapia
O3
Receptoresteciduais
Equiliacutebrio do metabolismo
SN neuro vegetativoSN central
pressatildeo
64
OZONIO EM CARDIOLOGIA amp ISQUEMIA EXPERIEcircNCIA CIENTIacuteFICA
Rokitansky AacuteustriaMatassi MilatildeoItaacutelia
RomeroCubaPoloniaHolanda De Monte Van der Zee
Lo PretteKraft( HAS)
BocciSiena ItaacuteliaDi Paolo Itaacuteli
Zhulina RuacutessiaHernandezCuba
Patterson amp RungeWasser
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 33
65
EXPERIEcircNCIA CLIacuteNICA COM O2+O3( INCOR GV) AHTM 264 pacientes com 5280 sessotildeesAHTm 232 pacientes com 2086 sessotildees
VR 292 pacientes com 6340 sessotildeesIArt 72 pacientes com 288 sessotildeesSC 212 pacientes com 848 sessotildees Bolsa toacutepica 346 pacientes com 7920
sessotildeesHidroozocircnio 420 pacientes com
9640sessotildeesTotal 1838 pacientes com 32402
sessotildees
66
OZONIO EM CARDIOLOGIA EXPERIEcircNCIA CLIacuteNICAEM
CardiomiopatiasArritmias Distuacuterbios de Conduccedilatildeo
Coronariopatias Distuacuterbios metaboacutelicos
Hipertensatildeo Arterial Doenccedila cerebrovascularVasculopatias perifeacutericas
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 34
67
68
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
74
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
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90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
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Autor Arnoldo de Souza 50
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Autor Arnoldo de Souza 51
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Autor Arnoldo de Souza 52
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Autor Arnoldo de Souza 53
105
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Autor Arnoldo de Souza 54
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108
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Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
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Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 35
69
70
Adelir Augusto Sesconete
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
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Autor Arnoldo de Souza 37
73
74
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Autor Arnoldo de Souza 38
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76
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Autor Arnoldo de Souza 39
77
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Autor Arnoldo de Souza 40
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Autor Arnoldo de Souza 41
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Autor Arnoldo de Souza 42
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Autor Arnoldo de Souza 43
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Autor Arnoldo de Souza 44
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Autor Arnoldo de Souza 47
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Autor Arnoldo de Souza 48
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Autor Arnoldo de Souza 49
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Autor Arnoldo de Souza 50
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Autor Arnoldo de Souza 51
101
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Autor Arnoldo de Souza 52
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Autor Arnoldo de Souza 53
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Autor Arnoldo de Souza 54
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108
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Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 36
71
72
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Autor Arnoldo de Souza 37
73
74
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Autor Arnoldo de Souza 38
75
76
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Autor Arnoldo de Souza 39
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Autor Arnoldo de Souza 40
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Autor Arnoldo de Souza 41
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Autor Arnoldo de Souza 42
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Autor Arnoldo de Souza 43
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Autor Arnoldo de Souza 44
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Autor Arnoldo de Souza 45
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Autor Arnoldo de Souza 46
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Autor Arnoldo de Souza 47
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Autor Arnoldo de Souza 48
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Autor Arnoldo de Souza 49
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Autor Arnoldo de Souza 50
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Autor Arnoldo de Souza 51
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Autor Arnoldo de Souza 52
103
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Autor Arnoldo de Souza 53
105
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21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 37
73
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Autor Arnoldo de Souza 38
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Autor Arnoldo de Souza 39
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Autor Arnoldo de Souza 40
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Autor Arnoldo de Souza 41
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Autor Arnoldo de Souza 42
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Autor Arnoldo de Souza 43
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Autor Arnoldo de Souza 45
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Autor Arnoldo de Souza 46
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Autor Arnoldo de Souza 47
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21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
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21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
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Autor Arnoldo de Souza 50
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Autor Arnoldo de Souza 51
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21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
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Autor Arnoldo de Souza 53
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Autor Arnoldo de Souza 54
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108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 38
75
76
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 39
77
78
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 40
79
80
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 41
81
82
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Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
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Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
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Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
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Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
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Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 42
83
84
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 43
85
86
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
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Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 44
87
88
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Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
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Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 45
89
90
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 46
91
92
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 47
93
94
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 48
95
96
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 49
97
98
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 50
99
100
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 51
101
102
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 52
103
104
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 53
105
106
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 54
107
108
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 55
109
110
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 56
111
Zh Nevrol Psikhiatr Im S S Korsakova 2012112(10)18-23
[The effect of ozone therapy on the activity of the autonomic nervous
system]
[Article in Russian]
Kuzmina VIu Khokhlov IuK Savin AA
Abstract
We studied 48 patients mean age 57 years 14 men 34 women with
chronic cerebrovascular disease and autonomic dysfunction Patients had
different types of autonomic response (sympathicotonic or normotonic)
Autonomic tone at baseline autonomic reactivity and autonomic supply of
activity were determined Patients were divided into 2 groups Patients of
the main group received ozone therapy along with standard medications
Patients of the control group received standard medications Disturbances
of vascular-autonomic regulation with the domination of ergotropic
sympathetic effects were identified in 697 of patients with chronic
cerebrovascular disease Ozone therapy caused a shift of the autonomic
balance towards the parasympathetic activity as well as the decrease in the
activity of the vasomotor center and the central regulation circuit that
indicates the increase in the power of defense mechanisms associated with
the normalization of autonomic balance
PMID 23250592 [PubMed - indexed for MEDLINE]
112
Cardiovasc Hematol Disord Drug Targets 2009 Jun9(2)78-85
May oxygen-ozone therapy improves cardiovascular disorders
Bocci V Travagli V Zanardi I
Source
Department of Physiology University of Siena Via Aldo Moro 2
53100 Siena Italy bocciunisiit
Abstract
In an aging population vascular disorders well exemplified by the
chronic limb ischemia chronic heart failure cerebral ischemia and
age-related macular degeneration represent a serious medical and
socio-economical problem While there is always a not easily
identifiable first pathogenic noxa all of these diseases are
characterized by ischemia chronic inflammation and tissue
degeneration Orthodox medicine has provided several optimal drugs
targeting various pathological situations but even with their
concomitant applications it is not possible to reduce the chronic
oxidative stress Here it is proposed to associate the approach of
ozonated autohemotherapy as a modifier of the biological response
capable to block the pathological progress
PMID 19519366 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 57
113
Voen Med Zh 2009 Aug330(8)30-2
[A complex medical rehabilitation of patients with coronary
heart disease underwent coronary shunting using air-ozone
baths]
[Article in Russian]
Shchegolkov AM Budko AA Sychev VV Azarova EK Arseniĭ TV
Abstract
Ozone therapeutics is one of not medicated methods of treatment of
coronary heart disease (CHD) For external application of ozone
therapeutics was elaborated an air-ozone bath Endurance of
procedure is 20 minutes ozone concentration is 8-10 mgl in
ozonized water and temperature of air-ozone mix is 36 degrees C
Course of treatment consisted of 10 daily procedures Searches are
founded on the base of analyze of results of remedial treatment of
160 patients with CHD Patient--men aged from 41 to 65 years
(average age is 556 +- 56) 130 patients of them underwent an
operation of coronary shunting (CS) admitted to unit on 7-18th day
after operation (in average--on 144 +- 36th) and 30 patients
without operational treatment Program of patient observe consisted
of general-clinical laboratorial functional and psychological
methods of searches It was established that using of air-ozone bath
in complex program of rehabilitation of patients with CHD after
operation of CS promotes to improvement of oxygen transporting
flow characteristics of blood microcirculation lowering of hypoxemia
and hypoxia of tissue
PMID 19916311 [PubMed - indexed for MEDLINE]
Publication Types MeSH Terms Substances
114
Blood Purif 200928(4)373-6 doi 101159000236365 Epub 2009
Sep 10
Oxygen-ozone therapy in medicine an update
Bocci V Di Paolo N
Source
Department of Physiology University of Siena Siena Italy
bocciunisiit
Abstract
Oxygen-ozone therapy initially started as an empirical approach
has now reached a stage where most of the biological mechanisms
of action of ozone have been clarified showing that they are in the
realm of orthodox biochemistry physiology and pharmacology Here
we have reviewed a few relevant clinical applications and have
shown that ozone therapy is particularly useful in cardiovascular
disorders and tissue ischemia In chronic viral infections it is unable
to eliminate the viremia but it may display supportive help by
stimulating the immune system Recently its use has been
successfully extended to the herniated disk pathology and therapy of
primary caries in children
Copyright 2009 S Karger AG Basel
PMID 19752547 [PubMed - indexed for MEDLINE]
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 58
115
Transplant Proc 2008 May40(4)974-7 doi 101016jtransproceed200803036
Preconditioning with ozone abrogates acute rejection and prolongs cardiac
allograft survival in rats
Stadlbauer TH Eisele A Heidt MC Tillmanns HH Schulz S
Source
Department of Internal Medicine Division of Cardiology Justus-Liebig-University
Giessen Germany ThomasStadlbauergmxde
Abstract
Acute cardiac allograft rejection remains a major cause of morbidity and mortality after
heart transplantation and predisposes for the development of graft vasculopathy The
aim of this study was to investigate the immunomodulatory effect of preconditioning of
the donor and recipient with medical ozone (O(3)O(2)) on acute allograft rejection
Minimizing the initial ischemia-reperfusion injury may result in a reduction of graft
vasculopathy and ameliorate long-term outcomes after cardiac transplantation Lewis
rats were challenged with Wistar-Furth cardiac allograft In donor and recipient animals
a medical ozone (O(3)O(2))-pneumoperitoneum was induced by single (1x) or
repetitive (5x) insufflation (concentration 50 microgmL 80 mLkg body weight) of
medical ozone intraperitoneally Without immunomodulatory therapy (n = 11) cardiac
allograft survival was 59 +- 09 days Preconditioning with medical ozone alone (single
bolus as well as repetitive administration n = 7) of the donor and recipient animals
prolonged cardiac allograft survival significantly to 76 +- 14 days (P lt 05) without
any adjunctive immunosuppressive therapy In this pilot study the intraperitoneal
administration of ozone in donor and recipient animals protected from ischemia-
reperfusion injury reduced the immunogenicity of the graft and prolonged cardiac
allograft survival Further studies are warranted to elucidate the underlying
mechanisms and--more important--to investigate the effect on the development of graft
vasculopathy the major obstacle to long-term graft and patient survivals
PMID 18555093 [PubMed - indexed for MEDLINE]
116
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 59
117
118
OZONIOTERAPIA EM CARDIOLOGIA
Natildeo esqueccedilamos jamais que as ideacuteias satildeo menos interessantes que os seres humanos que as inventam modificam aperfeiccediloam ou traem
Franccedilois TruffautObrigado
Arnoldo de Souza arnoldoscardiolbr
Arnoldo de Souza arnoldoscardiolbr
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 60
119
120
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 61
121
122
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 62
123
124
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 63
125
126
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127
21O Curso de Ozonioterapia 9242016
Autor Arnoldo de Souza 64
127