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Pesquisa: 601299[Identificadornico]Totaldereferncias: 1

1/1Id: 601299 LILACSExpress

Autor: Silva,AnnelisaFarahdaGirardi,JosMarcosRaposo,NdiaResendeBarbosa.Ttulo: UsodasestatinasnadoenadeAlzheimer:umareviso/Statinsanditsusein

Alzheimerdisease:areviewFonte: HUrev36(3),jul.set.2010.

Idioma: pt.Resumo: ADoenadeAlzheimer(DA),caracterizadapelaperdadamemriaedepelomenos

outrafunocognitiva,setornoufocodeatenoporpartedospesquisadores,tendoemvistaoaumentodesuaprevalncianapopulaomundial.Apresenadasplacasneurticas,formadaspeloacmulodopeptdeobetaamilideedosemaranhadosneurofibrilaressoasprincipaisalteraesneuropatolgicascaractersticasdaDA.Estasalteraessoresponsveispeloprocessodeneurodegeneraoepelodesenvolvimentoprogressivodademncia.EstudosdemonstrammenorprevalnciaeriscoparaaDAemusurioscrnicosdeestatinas,frmacoshipocolesterolmicos.OobjetivodestarevisofoireunirpartedosestudosdaliteraturaqueprevilegiassearelaoentreasestatinaseaDA.Hindciosdequetaisfrmacospodemdesacelerarodeclniocognitivoereduziroritmoevolutivodadoena,atravsdeseusefeitospleiotrpicos,dasatuaesnafunoendotelial,dainibiodasntese?amilideedareduodoimpactodoemaranhadoneurofibrilar.Acreditasequehumaligaosignificativaentreoselevadosnveisdecolesterolnasclulasneuronais,ousodeestatinaseoprognsticodepacientescomaDA.(AU)

AlzheimersDisease(AD),whichischaracterizedbymemorylossandatleastanothercognitivedysfunction,becamefocusedbyresearchersduetoitsincreasingprevalenceinworldspopulation.Neuriticplaques,structuredbytheaccumulationofthepeptidebetaamyloidandtheneurofibrillarytanglesarethemainneuropathlogicalalterationsfoundinAD.Neurodegenerationandtheprogressivedevelopmentofdementiaareaconsequenceofthesealterations.Studiesobservedthatstatins(hypocholesterolemicdrugs)chronicusershavealowerprevalenceandadecreasedriskforAD.TheliteraturewasrevisedtargetingtherelationbetweenstatinsandAD.Thereisevidencethatthesedrugscandeacceleratethecognitivedeclineandreducethediseasesevolutiverhythmthrough:pleiotropiceffects,performanceconcerningendothelialfunction,inhibitionofbetaamyloidssynthesisandreductionofneurofibrillarytanglesimpact.Thus,thereisanoteworthyconnectionregardinghighcholesterollevelsintheneurons,statinuseandtheprognosisofpatientswithAD.(AU)

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