BIO DATA

NAME Dr. K. Kemparaju

DESIGNATION Professor of Biochemistry

DATE OF BIRTH 20th July, 1964

ORGANIZATION Department of Studies in Biochemistry

University of Mysore,

Manasagangotri, Mysore – 570 006, India.

HOME ADDRESS # 17, 8th Main, D` Block, 3rd Stage,

Vijayanagar, Mysore – 570 017, Karnataka.

EMAIL kemparajuom@gmail.com

kemparaj@biochemistry.uni-mysore.ac.in

CELL # +9945996543

EDUCATIONAL QUALIFICATIONS

Under-graduate

B.Sc. Degree C B Z [Chem., Bot., Zool.] (Top Grade)

(1985) Yuvaraja`s College

University of Mysore, Mysore.

Post-graduate

M.Sc. Degree Biochemistry (Top grade/First Class)

(1987) Dept. of Biochemistry

University of Mysore, Mysore.

Doctoral Biochemistry

(1996) Dept. of Biochemistry

University of Mysore, Mysore.

(1987) Dept. of Biochemistry

Indian Institute of Science

Bangalore – 560012.

Post-doctoral Post doctoral fellow, Albert Einstein College of Medicine,

(2003) Bronx, New York, USA.

TEACHING AND RESEARCH EXPERIENCE

From 2009 Professor of Biochemistry

2002-2003 Post doctoral fellow, Albert Einstein College of Medicine,

Bronx, New York, USA.

2001- 2009: Associate Professor of Biochemistry,

1996-2001: Senior Lecturer in Biochemistry, University of Mysore.

1988-1996: Lecturer in Biochemistry, Univ. of Mysore.

1987–1988: Ph.D. student, Dept. of Biochemistry, Indian Institute of

Science, Bangalore.

RESEARCH SPECIALIZATION Pharmacology of snakes and spider venoms, special emphasis on hyaluronidases, and

metalloproteases in local toxicity. Geographical variations of snake venoms and venom neutralization. Venom components of therapeutic importance, emphasis on thrombosis and

hemostasis. Extracellular matrix biology.

CITATION INDEX (h): 16 i-10 index: 24 TOTAL CITATIONS: Total: 812 661 (Since 2008) CITATIONS IN: Nature Reviews Immunology

Nature Reviews in Cancer Pharmacological Reviews Medicinal Research Reviews

MOST CITED PAPER: Life Sciences RESEARCH RECOGNITION: Our group is recognized for the extensive work done on hyaluronidase enzyme which for the first time we highlighted as a therapeutic target in the management of snakebite. Further, THE TELEGRAPH, the national daily news paper has recognized and cited the research contribution of our group in August 26th 2012 issue.

TEACHING (Post-graduate and Ph.D. students)

Immunology Enzymology Biochemical techniques Bio-organic chemistry Bioinorganic chemistry Carbohydrate Metabolism Signal transduction

SUPERVISOR FOR Ph.D. STUDENTS Awarded Submitted Working 9 1 5

ACADEMIC DISTINCTIONS

Professor of Biochemistry, Dept. of Biochemistry, University of Mysore, Mysore.

Doctoral Student, Dept. of Biochemistry, Indian Institute of Science, Bangalore.

Post Doctoral Fellow, Albert Einstein College of Medicine, New York, USA.

Guided 9 students for Ph.D. Degree in Biochemistry, Univ. of Mysore, Mysore.

Guided 1 student for M. Phil. Degree in Biochemistry.

Guest Editor, for the Special Issue “Current Topics in Medicinal Chemistry”. An International Journal, Bentham Publishers, Impact Factor 4.2.

Secured best presentation award at an International conference organized by National

University of Singapore, Singapore, 2010.

Invited speaker in National & International symposia/Conferences.

Chaired sessions in National Conferences.

Reviewer for International and National Journals of high repute.

Reviewed research proposals submitted for funding to DST, New Delhi.

Member, BOS and BOE of different Universities.

Organizing Secretary/Joint Organizing Secretary/Treasurer/member in organizing

several National Conferences at our department.

Resource person for Academic Colleges of different universities, PU Board, Govt. of Karnataka.

Resource Person, PAC programme for All India Kendriya Vidyalaya Teachers,

organized by R I E, Mysore.

KEY NOTE / INVITED TALKS DELIVERED IN NATIONAL AND

INTERNATIONAL SYMPOSIA

K. Kemparaju; Trends in protein science: search for novel bioactive peptides (Key

note; National Symposium jointly organized by Tumkur University and Council for

Higher Education, Govt. of Karnataka (2013).

K. Kemparaju; Variations in venom composition due to geographic distribution of

the snake, impact on snakebite management, National symposium organized by Dept.

of Biochemistry, Univ. of Mysore, Mysore, 2012.

K. Kemparaju; Snake venom metalloproteases, structure, function and role in

hemostasis, Tthree days National work shop organized at the Dept. of Biochemistry,

Univ. of Mysore, Mysore by the International Society on Hemostasis, 2012.

K. Kemparaju; Snake venom Toxins as analytical, diagnostic and therapeutic tools,

National symposium, Organized by Dept. of Biochemistry, Tumkur University in

association with Higher Education Council, Karnataka, 2012.

K. Kemparaju; Current trends immunology, National symposium organized by,

Dept. of Microbiology, Kuvempu University, Karnataka, 2011.

K. Kemparaju, Snake venom toxins as tools in Biology, National symposium

organized by Dept. of Biotechnology, Sridevi Engineering College, Tumkur, 2011.

K. Kemparaju; The non toxic fibrin(ogen)olytic enzyme from Naja naja venom:

inhibition of collagen induced human platelet aggregation by affecting alpha-2, beta-1

and GP-VI. 2010, State level Refresher Course for pre-University Teachers, Suttur,

Mysore, India.

K. Kemparaju; Neutralization Vipera russellii venom and its purified hemorrhagin

by gallic acid, 2009, Medical Biotechnology on Clinical research, J, N. Tata

Auditorium, IISc Campus, Bangalore.

K. Kemparaju; Local effects of snakebite: possible therapeutic targets for the better

management. 2008, Little flower Hospital and Research Center, Angamaly, Kochin ,

kerala, India.

K. Kemparaju; NN-PF3 is a fibrin(ogen)olytic enzyme from Naja naja venom.

2009, Dept. Biochemistry and Biotechnology, Annamalai University, Annamalai

nagar, Tamilnadu, India.

K. Kemparaju; The metzincin Partitagin is a unique Beta fibrinogenase from

Hippasa partita spider venom that inhibits platelet aggregation. 2008; Dept. of

Biochemistry and Biotechnology, Annamalai University, Annamalai nagar,

Tamilnadu, India.

K. Kemparaju; Hyaluronidase : a potential target in the management of

snakebite,2007; School of Biotechnology, Chemical and Biomedical Engineering,

VIT University, Vellore, Tamilnadu, India.

K. Kemparaju; Geographical variation of Naja naja venom: an important factor in

making therapeutic antivenom. 2005; Dept. of Biochemistry and Biotechnology,

Annamalai University, Annamalai nagar, Tamilnadu, India.

RESEARCH PROJECTS

Sl. No.

Principal/Co-investigator

Title of the project Supporting agency

Year Amount

1 Principal Investigator

Studies on the molecular mechanism of anticoagulant and antiplatelet properties of the fibrinogenase from Indian cobra(Naja naja) Venom

DST, New Delhi.

2006 22,15 lakhs

2 Principal Investigator

Preparation of antivenom and cross-reactivity of Indian King cobra (Ophiophagus hannah) venom

UGC, New Delhi.

2009 11.35 lakhs

3 Co-investigator Guggul proteins: Exploring the role in hemostasis

UGC, New Delhi.

2009 11.75 lakhs

4 Principal Investigator

Local toxicity of viper venoms: Neutralization by extracts of medicinal plants

Institute of Excellence, University of

2010 About 15 Lakhs

Mysore. 5 Co-investigator Plant based therapeutics; A

better approach to treat arthritis Institute of Excellence, University of Mysore.

2010 About 15 Lakhs

PUBLICATIONS: 1. Sebastin Santhosh M, Shanmuga Sundaram M, Sunitha K, Kemparaju K, Girish KS.

Viper Venom Induced Oxidative Stress and Activation of Inflammatory Cytokines: A Therapeutic Approach for Overlooked Issues of Snakebite Management. Inflammation Research. 2013 (in press).

2. Hemshekhar M, Thushara RM, Sunitha K, Devaraja S, Kemparaju K, Girish KS. Attenuation of adjuvant-induced arthritis by dietary sesamol via modulation of inflammatory mediators, extracellular matrix degrading enzymes and antioxidant status. European Journal of Nutrition. 2013 (in press).

3. Sebastin Santhosh M, Thushara RM, Hemshekhar M, Sunitha K, Devaraja S, Kemparaju K, Girish KS. Alleviation of viper venom induced platelet apoptosis by crocin (Crocus sativus): implications for thrombocytopenia in viper bites. Journal of Thrombosis & Thrombolysis. 2013 (in press).

4. Sunitha K, Hemshekhar M, Thushara RM, Sebastin santhosh M, Yariswamy M, Kemparaju K. Girish KS. N-Acetylcysteine amide: A derivative to fulfill the promises of N-Acetylcysteine. Free Radical Research. 2013, 47(5):357-367.

5. Hemshekhar M, Sunitha K, Thushara RM, Sebastin santhosh M, Shanmuga sundaram M, Kemparaju K, Girish KS. Anti-arthritic and anti-inflammatory propensity of 4-Methylesculetin, a coumarin derivative. Biochimie. 2013, 95 (2013):1326-1335.

6. Sunitha K, Suresh P, Sebastin Santhosh M, Hemshekhar M, Thushara RM, Gopal K Marathe, Thirunavukkarasu C, Kemparaju K, Suresh Kumar M, Girish KS. Inhibition of hyaluronidase by N-acetyl cysteine and glutathione: Role of thiol group in hyaluronan protection. International Journal of Biological Macromolecules. 2013. 55(2013):39-46.

7. Devaraja S, Girish KS, Sebastin santhosh M, Hemshekhar M, Nayaka SC, Kemparaju K. Fusaric acid, a Mycotoxin: Influence on blood coagulation and platelet function. Blood Coagulation & Fibrinolysis 2013, 24(4):419-423.

8. Nagaraju PM, Praveen US, Kemparaju K, Mohan BM. Separation evaluation of selected organophosphorus fungicides by NP-TLC and RP-HPTLC. Asian J. Research Chem 2013 6(2), 148-154.

9. Thushara RM, Hemshekhar M, Sebastin santhosh M, Devaraja S, Kemparaju K, Girish KS*. Differential action of phytochemicals on platelet apoptosis: A biological overview. Current Medicinal Chemistry. 2013, 20 (8), 1018-1027.

10. Jnaneshwari S, Hemshekhar M, Sebastin Santhosh M, Sunitha K, Thushara RM, Thirunavukkarasu C, Kemparaju K, Girish KS. Crocin, a dietary colorant mitigates the cyclophosphamide induced organ toxicities by modulating antioxidant status and inflammatory cytokines. Journal of Pharmacy & Pharmacology. 2013, 65(4):604-14.

11. Thushara RM, Hemshekhar M, Santhosh MS, Jnaneshwari S, Nayaka SC, Naveen S, Kemparaju K, Girish KS. Crocin, a dietary additive protects platelets from oxidative stress-induced apoptosis and inhibits platelet aggregation. Molecular & Cellular Biochemistry. 2012. 373(1-2):73-83.

12. Hemshekhar M, Sebastin Santhosh M, Sunitha K, Thushara RM, Kemparaju K, Rangappa KS, Girish KS. A dietary colorant crocin mitigates arthritis and associated secondary complications by modulating cartilage deteriorating enzymes, inflammatory mediators and antioxidant status. Biochimie. 2012. 94(12):2723-33.

13. Sebastin Santhosh M, Hemshekhar M, Sunitha K, Thushara RM, Jnaneshwari S, Kemparaju K, Girish KS. Snake venom induced local toxicities: Plant secondary metabolites as an auxiliary therapy. Mini-reviews in Medicinal Chemistry. 2013. 13, 106-123.

14. M. Sebastin Santhosh, M. Hemshekhar, R.M. Thushara, S. Devaraja, K. Kemparaju, K.S. Girish. Vipera russelli venom induced oxidative stress and hematological alterations: Amelioration by crocin a dietary colorant. Cell Biochemistry and Function. 2013. 31(1):41-50.

15. Yashonandana J Goutham, Kumar MS, Girish KS, Kemparaju K. Hemostatic interference of Indian King cobra (Opiophagus hannah) venom: Comparison with three snake venoms of the sub-continent. Biochemistry (Moscow). 77(6):639-647, 2012.

16. Hemshekhar M, Sebastin Santhosh M, Kemparaju K, Girish KS. Emerging Roles of Anacardic Acid and Its Derivatives: A Pharmacological Overview. Basic Clin Pharmacol Toxicol, 110, 122–132, 2012.

17. Nagaraju PM, Praveen US, Kemparaju K, Mohan BM. Evaluation of Separation Parameters for Selected Organophosphorus Fungicides of Forensic mportance by RP-HPTLC. Acta Chromatographica 2012, 24, 1–10.

18. Nagaraju S, Girish KS, Pan Y, Easely KA, Kemparaju K. Estimation of serum hyaluronidase activity overcoming the turbidity interference. Clinical Laboratory Science 24: 172-177, 2011.

19. Hemshekhar M, Sunitha K, Sebastin Santhosh M, Devaraja S, Kemparaju K, Vishwanath BS, Niranjana S.R and Girish KS. An overview on Genus Garcinia: Phytochemical and therapeutical aspects. Phytochemistry Reviews 10: 325-351, 2011.

20. KS Girish and K Kemparaju. Overlooked Issues of Snakebite Management: Time for Strategic Approach. Current Topics in Medicinal Chemistry 11: 2494-2508, 2011.

21. YH Mahadeswaraswamya, MS Kumar, Yashonandana J Gowthama, S Nagaraju, KS Girish and K Kemparaju. The Polyphenol 3, 4, 5 - Tri-hydroxy Benzoic Acid Inhibits Indian Daboia russelli Venom and Its Hemorrhagic Complex Induced Local Toxicity. Current Topics in Medicinal Chemistry, 2011, 11, 2520-2530.

22. K Kemparaju. Snakebite management: time for strategic approach. Curr. Top. Med. Chem. 2011, 11(20) 2493.

23. K Sunitha, M Hemshekhar, SL Gaonkar, M Sebastin Santhosh, M Suresh kumar2 Basappa, BS Priya, K Kemparaju, KS Rangappa, S Nanjunda Swamy, KS Girish. Neutralization of Haemorrhagic Activity of Viper Venoms by 1-(3-Dimethylaminopropyl)-1-(4-Fluorophenyl)-3-Oxo-1, 3-1 Dihydroisobenzofuran-5-Carbonitrile. Basic & Clinical Pharmacology & Toxicology. 2011, 109(4), 292-299.

24. Nagaraju PM, Praveen US, Kemparaju K, Mohan BM.Separation of organophosphorus fungicides by high-performance thin-layer chromatography: A new approach in forensic analysis. Journal of Planar Chromatography 2011, 24, 108–112.

25. YH Mahadeswaraswamy, B Manjula, S Devaraja, KS Girish and K Kemparaju. Daboia russelli Venom Hyaluronidase: Purification, Characterization and Inhibition by β-3-(3-Hydroxy-4-Oxopyridyl) α-Amino-Propionic Acid. Current Topics in Medicinal Chemistry, 2011, 11, 2556-2565.

26. S Nagaraju, K Kemparaju. ‘Partitagin’, a unique β, ϒ-fibrinogenase that inhibits platelet aggregation from Hippasa partita spider venom. Blood Coagul. Fibrinolysis 2011, 22(1), 24-28.

27. M Hemshekhar, K Sunitha, M Sebastin Santhosh, S Devaraja, K Kemparaju, BS Vishwanath, SR Niranjana, KS Girish. An overview on genus garcinia: phytochemical and therapeutical aspects. Phytochem Rev. 2011, 10, 325–351.

28. MS Kumar & KS Girish & BS Vishwanath & K Kemparaju. The metalloprotease, NN-PF3 from Naja naja venom inhibits platelet aggregation primarily by affecting α2β1 integrin. Ann Hematol 2011, 90:569–577.

29. S Devaraja , KS Girish, YNJ Gowtham, K Kemparaju. The Hag-protease-II is a fibrin(ogen)ase from Hippasa agelenoides spider venom gland extract: Purification, characterization and its role in hemostasis. Toxicon 57 (2011) 248–258.

30. S Nagaraju, KS Girish, Yi Pan, Kirk A Easely, K Kemparaju. Estimation of Serum Hyaluronidase Activity: overcoming the turbidity interference. Clinical Laboratory Science, 2011, 24 (3) summer 172-177.

31. Kumar MS, Devaraj VR, Vishwanath BS, Kemparaju K. Anti-coagulant activity of a metalloprotease: further characterization from the Indian cobra (Naja naja) venom. J Thromb Thrombolysis. 2010, 29(3), 340-348.

32. Devaraja S, Girish KS, Devaraj VR, Kemparaju K. Factor Xa-like and fibrin(ogen)olytic activities of a serine protease from Hippasa agelenoides spider venom gland extract. J Thromb Thrombolysis. 2010 Jan; 29(1):119-26.

33. Ushanandini S, Nagaraju S, Nayaka SC, Kumar KH, Kemparaju K, Girish KS. The anti-ophidian properties of Anacardium occidentale bark extract. Immunopharmacol Immunotoxicol. 2009; 31(4):607-15.

34. Shashidharamurthy R, Mahadeswaraswamy YH, Ragupathi L, Vishwanath BS, Kemparaju K. Systemic pathological effects induced by cobra (Naja naja) venom from geographically distinct origins of Indian peninsula. Exp Toxicol Pathol. 2010, 62(6), 587-592.

35. Girish KS, Kemparaju K, Nagaraju S, Vishwanath BS. Hyaluronidase inhibitors: a biological and therapeutic perspective. Curr Med Chem. 2009; 16(18):2261-88. Review.

36. Mahadeswaraswamy YH, Devaraja S, Kumar MS, Goutham YN, Kemparaju. K. Inhibition of local effects of Indian Daboia/Vipera russelli venom by the methanolic extract of grape (Vitis vinifera L.) seeds. Indian J Biochem Biophys. 2009 Apr; 46(2):154-60.

37. Chandrashekara KT, Nagaraju S, Nandini SU, Basavaiah, Kemparaju K. Neutralization of local and systemic toxicity of Daboia russelii venom by Morus alba plant leaf extract. Phytother Res. 2009 Aug; 23(8):1082-7.

38. Sharma R, Mahadeswaraswamy YH, Harish Kumar K, Devaraja S, Kemparaju K, Vishwanath BS, Girish KS. Effect of anticoagulants on the plasma hyaluronidase activities. J Clin Lab Anal. 2009; 23(1):29-33.

39. Devaraja S, Nagaraju S, Mahadeswaraswamy YH, Girish KS, Kemparaju K. A low molecular weight serine protease: Purification and characterization from Hippasa agelenoides (funnel web) spider venom gland extract. Toxicon. 2008 Jul; 52(1):130-8.

40. Mahadeswaraswamy YH, Nagaraju S, Girish KS, Kemparaju K. Local tissue destruction and procoagulation properties of Echis carinatus venom: inhibition by Vitis vinifera seed methanol extract. Phytother Res. 2008 Jul; 22(7):963-9.

41. S Nagaraju, KS Girish, JW Fox, K Kemparaju. Partitagin’ a hemorrhagic metalloprotease from Hippasa partita spider venom: Role in tissue necrosis. Biochimie 2007, 89 1322-1331.

42. Nagaraju S, Devaraja S, Kemparaju K. Purification and properties of hyaluronidase from Hippasa partita (funnel web spider) venom gland extract.Toxicon. 2007 Sep 1; 50(3):383-93. Epub 2007 Apr 24.

43. Girish KS, Kemparaju K. The magic glue hyaluronan and its eraser hyaluronidase: a biological overview. Life Sci. 2007 May 1; 80(21):1921-43. Review.

44. Shashidharamurthy R, Kemparaju K. Region-specific neutralization of Indian cobra (Naja naja) venom by polyclonal antibody raised against the eastern regional venom:

A comparative study of the venoms from three different geographical distributions. Int Immunopharmacol. 2007 Jan; 7(1):61-9.

45. Girish KS, Machiah KD, Ushanandini S, Harish Kumar K, Nagaraju S, Govindappa M, Vedavathi M, Kemparaju K. Antimicrobial properties of a non-toxic glycoprotein (WSG) from Withania somnifera (Ashwagandha). J Basic Microbiol. 2006; 46(5):365-74.

46. Nagaraju S, Mahadeswaraswamy YH, Girish KS, Kemparaju K. Venom from spiders of the genus Hippasa: biochemical and pharmacological studies. Comp. Biochem Physiol C Toxicol Pharmacol. 2006 Sep; 144(1):1-9.

47. Ushanandini S, Nagaraju S, Harish Kumar K, Vedavathi M, Machiah DK, Kemparaju K, Vishwanath BS, Gowda TV, Girish KS. The anti-snake venom properties of Tamarindus indica (leguminosae) seed extract. Phytother Res. 2006 Oct; 20(10):851-8.

48. Shashidharamurthy R, Kemparaju K. A neurotoxic phospholipase A2 variant: isolation and characterization from eastern regional Indian cobra (Naja naja) venom. Toxicon. 2006 Jun 1; 47(7):727-33.

49. Girish KS, Kemparaju K. Inhibition of Naja naja venom hyaluronidase: role in the management of poisonous bite. Life Sci. 2006 Feb 23; 78(13):1433-40.

50. Kemparaju K, Girish KS. Snake venom hyaluronidase: a therapeutic target. Cell Biochem Funct. 2006 Jan-Feb; 24(1):7-12. Review.

51. Girish KS, Kemparaju K. Inhibition of Naja naja venom hyaluronidase by plant-derived bioactive components and polysaccharides. Biochemistry (Mosc). 2005 Aug; 70(8):948-52.

52. Girish KS, Kemparaju K. A low molecular weight isoform of hyaluronidase: purification from Indian cobra (Naja naja) venom and partial characterization. Biochemistry (Mosc). 2005 Jun; 70(6):708-12.

53. Rajesh R, Raghavendra Gowda CD, Nataraju A, Dhananjaya BL, Kemparaju K, Vishwanath BS. Procoagulant activity of Calotropis gigantea latex associated with fibrin(ogen)olytic activity. Toxicon. 2005 Jul; 46(1):84-92.

54. Girish KS, Mohanakumari HP, Nagaraju S, Vishwanath BS, Kemparaju K. Hyaluronidase and protease activities from Indian snake venoms: neutralization by Mimosa pudica root extract. Fitoterapia. 2004 Jun;75(3-4):378-80.

55. Girish KS, Shashidharamurthy R, Nagaraju S, Gowda TV, Kemparaju K. Isolation and characterization of hyaluronidase a "spreading factor" from Indian cobra (Naja naja) venom. Biochimie. 2004 Mar; 86(3):193-202.

56. Girish KS, Jagadeesha DK, Rajeev KB, Kemparaju K. Snake venom hyaluronidase: an evidence for isoforms and extracellular matrix degradation. Mol. Cell Biochem. 2002 Nov; 240(1-2):105-10.

57. Jagadeesha DK, Shashidhara murthy R, Girish KS, Kemparaju K. A non-toxic anticoagulant metalloprotease: purification and characterization from Indian cobra (Naja naja naja) venom. Toxicon. 2002 Jun;40(6):667-75.

58. Variations in biochemical and pharmacological properties of Indian cobra (Naja naja naja) venom due to geographical distribution. Shashidharamurthy R, Jagadeesha DK, Girish KS, Kemparaju K. Mol. Cell Biochem. 2002 Jan; 229(1-2):93-101.

59. Kemparaju K, Krishnakanth TP, Veerabasappa Gowda T. Purification and characterization of a platelet aggregation inhibitor acidic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) venom. Toxicon. 1999 Dec; 37(12):1659-71.

60. Prasad BN, Kemparaju K, Bhatt KG, Gowda TV. A platelet aggregation inhibitor phospholipase A2 from Russell's viper (Vipera russelli) venom: isolation and characterization. Toxicon. 1996 Oct; 34(10):1173-85.

61. Kemparaju K, Prasad BN, Gowda VT. Purification of a basic phospholipase A2 from Indian saw-scaled viper (Echis carinatus) venom: characterization of antigenic, catalytic and pharmacological properties. Toxicon. 1994 Oct; 32(10):1187-96.

BOOK CHAPTERS

K Kemparaju, KS Girish, S Nagaraju. Hyaluronidases, a Neglected Class of Glycosidases from Snake Venom, Beyond a Spreading Factor. (Reptile Venoms and Toxins by S. Meckessy, IRL Press, USA.) 235 to 256, 2009.

Hemshekhar M, Kemparaju K, Girish KS (2011). Tamarind (Tamarindus indica) seeds: an overview on remedial qualities. In V. R. Preedy, R. R. Watson, V. B. Patel (Editors), Nuts & Seeds in Health and Disease Prevention (1st ed.) (pp 1107-1114). London, Burlington, San Diego: Academic Press is an imprint of Elsevier.

Girish KS, Devaraja S, Thushara RM, Hemshekhar M, Kemparaju K, Jayaramu M. Bioscaffold Based Treatment Options for Tendon Repair and Regeneration. Book chapter in “Collection of Lectures on Discovery and Applications of Innovative Materials” Edited by Prof. S.C. Sharma and Prof. K.M. Kaveriappa, Karnataka State Higher Education Council, November 2012 (ISBN #: 978-81-923301-5-0)

POSTERS PRESENTED AT NATIONAL AND INTERNATIONAL SYMPOSIA:

Sebastin santhosh M, Shanmuga Sundaram M, Sunitha K, Hemshekhar M, Kemparaju K, Girish KS. Propensity of crocin, an antioxidant carotenoid to offset Vipera russelli venom induced inflammation and apoptosis in blood components by inhibiting oxidative stress. “National conference on Snakebite management”. Dec 10th- 12th 2012. (Best poster presentation award, Third prize).

Hemshekhar M, Thushara R Mohan, Sebastin santhosh M, Shanmuga Sundaram M, Kemparaju K, Girish KS. Crocin, a dietary colorant alleviates arthritis and

associated secondary complications. National Conference on “Emerging Trends in Ayurveda and Herbal drug Technology”. Nov 22nd – 23rd 2012. (Best poster presentation award, Second prize).

Mahadeswraswamy YH, Girish KS and Kemparaju K. Local toxicity of Indian Daboia/Vipera russellii venom and its purified hemorrhagic complex: Contribution for the better management. National conference on Medical Biotechnology and Clinical research. October 2009. Department of Biotechnology, Sri. M. Visvesvaraya Institute of Technology and Sri Krishnadevaraya Education Trust, JN Tata Auditorium, Indian Institute of Science campus, Bangalore, India. (Best poster presentation award, second prize).

Mahadeswaraswamy YH and Kemparaju K. Screening of Indian medicinal plants for anti-venom property against Indian Daboia/ Vipera russellii and Echis carinatus venoms. Dr. Norman E. Borlaug commemoration national conference on “Plant diversity and plant health”. March 2010, Department of Studies in Botany, University of Mysore, Mysore. India.

Mahadeswraswamy Y.H, Girish K.S and Kemparaju, K. Antivenom potential of Gallic acid against the Indian Daboia/Vipera russellii venom and its purified hemorrhagic complex. State level conference on Recent advances in Environmental Science and Engineering. October, 2009. Department of Biotechnology and Engineering, Shridevi Institute of Engineering and Technology, Tumkur, India.

Devaraja S and Kemparaju K. A low molecular weight serine protease the Hag-protease from Hippasaagelenoides spider venom gland extract: Role in fibrin(ogen)olysis andplatelet function. International conference on `cardiovascular diseasessecondary to the metabolic disorders: Mechanism and therapy`.December, 2009. Department of Studies in Biochemistry, University of Mysore, Mysore. India.

Mahadeswaraswamy YH and Kemparaju K. Gallic acid: a potent inhibitor of Indian Daboia russellii venom and its purified hemorrhagic complex induced local toxicity. National symposium on Bioactive molecules: from discovery to industry. April 2009. Department of Studies in Biochemistry, University of Mysore, Mysore. India.

Mahadeswaraswamy YH and Kemparaju K. Local tissue destruction property of Indian Daboia /Vipera russellii venom and its purified hemorrhagic complex: Inhibition by Gallic acid. National conference on Recent trends in animal physiology. October, 2009, Department of Studies in Zoology, University of Mysore, Mysore. India.

Devaraja S and Kemparaju K. Local and systemic toxicity of Hag-protease a low molecular weight serine protease from Hippasa agelenoides spider venom gland extract. National symposium on Recent Trends in Animal Physiology. October 2009. Department of Studies in Zoology, University of Mysore, Mysore. India

Mahadeswraswamy YH, Girish KS and Kemparaju K. Local toxicity of Indian Daboia/Vipera russellii venom and its purified hemorrhagic complex: Contribution

for the better management. National conference on Medical Biotechnology and Clinical research. October 2009. Department of Biotechnology, Sri. M. Visvesvaraya Institute of Technology and Sri Krishnadevaraya Education Trust, JN Tata Auditorium, Indian Institute of Science campus, Bangalore, India.

Yashonandana J Gowtham, Sadiq Saleh Ahmed, Naveen H M and K Kemparaju. The Indian King Cobra (Ophiophagus hannah) Venom: A preliminary study. National symposium on Bioactive molecules: from discovery to industry. April 2009. Department of Studies in Biochemistry, University of Mysore, Mysore. India.

Yashonandana J Gowtham and K Kemparaju. The Indian King Cobra (Ophiophagus hannah) Venom strongly interferes in Hemostasis. National conference on Recent trends in animal physiology. October, 2009, Department of Studies in Zoology, University of Mysore, Mysore. India.

Devaraja S and Kemparaju K. Hag-protease from Hippasa agelenoides spider venom extract: Role in tissue necrosis and hemostasis. National symposium on Bioactive molecules: from discovery to industry. April 2009. Department of Studies in Biochemistry, University of Mysore, Mysore.

Rashmi K, Zahara Ashkavand, Devaraja S and K Kemparaju. preliminary studies on proteolytic activity of cucumber sap extract. Nationalsymposium on Bioactive molecules: from discovery to industry. April2009. Department of Studies in Biochemistry, University of Mysore, Mysore.

Mahadeswaraswamy YH and Kemparaju K. Local effects of snakebite: Possible therapeutic targets for the better management. International symposium on Snakes, venoms and snake bites. SNA-CON October 2008, Angamaly, Cochin.

Girish. K.S., Nagaraju, S., and Kemparaju, K. Hyaluronidase: a potential target in the management of snakebite. 3rd National Symposium on Venoms and Toxins. Dept. of Biochem. Univ. of Mysore (2004).

Nagaraju S, Girish KS, and Kemparaju K. Spider venom: comparative characterization from three different species (Hippasa). 3rd National Symposium on Venoms and Toxins. Dept. of Biochem. Univ. of Mysore (2004).

Kemparaju K and Girish KS. A pharmacological examination of the Indian saw-scaled viper venom. 28, Proc. National Symp. On Proteins in Biology, Mysore, India (1999).

Jagadeesha DK, Shashidhara murthy R and Kemparaju K. Isolation and characterization of a non-toxic fibrinogenase from Indian cobra (Naja naja) venom. 48, Proc. National Symp. On Proteins in Biology, Mysore, India (1999).

Shashidhara murthy R, Jagadeesha DK and Kemparaju K. Isolation, characterization and chemical modification of histidine and lysine residues of a neurotoxic phospholipase A2 from Indian cobra (Naja naja) venom. 55, Proc. National Symp. On Proteins in Biology, Mysore, India (1999).

Kemparaju K and Gowda TV. Comparative characterization of phospholipases A2 from Indian saw-scaled viper (Echis carinatus) venom. 324, 64th Annual Meeting of SBC, Lucknow, India (1995).

Kemparaju K and Gowda TV. Selective neutralization of enzymatic activity of a toxic phospholipase A2 from Echis carinatus venom by polyclonal antibodies, P7-82, XVIth IUBMB meeting, India (1994).

Kemparaju K and Gowda TV. Purification and characterization of a toxic phospholipase A2 (EC-PLA2-IV) from Indian saw-scaled viper (Echis carinatus) venom. PEFD 019, 197, 62nd Annual Meeting of SBC, Madurai, Inida (1993).

Kemparaju K and Gowda TV. Preliminary studies on Indian saw-scaled viper (Echis carinuatus) venom. Abstract No. 365, 61st Annual Meeting of SBC, Hyderabad, India (1992).

Kemparaju K, Kasturi S and Gowda TV. Effect of trypsin digestion on the enzymatic and edema inducing activities of Vipera russelli phospholipase A2 A4-9, 15, Second Asia-Pacific congress on Animal, plant and microbial Toxins, Varanasi, India (1990).

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