Farmacodinâmica
-
Upload
vinicius-henrique -
Category
Education
-
view
20.174 -
download
3
Transcript of Farmacodinâmica
![Page 1: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/1.jpg)
Farmacodinâmica
Prof. MSc. Vinicius Henrique
Farmacêutico Clínico
![Page 2: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/2.jpg)
FARMACODINÂMICA
Área da farmacologia que estuda os mecanismos de
ação dos fármacos, assim como sua interação com
o alvo.
![Page 3: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/3.jpg)
Fármacos não CRIAM efeitos no
organismo, eles MODIFICAM uma
função já existente!!!!!
![Page 4: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/4.jpg)
MECANISMOS GERAIS DE SINALIZAÇÃO
CELULAR
![Page 5: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/5.jpg)
MECANISMOS GERAIS DE SINALIZAÇÃO
CELULAR
![Page 6: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/6.jpg)
MECANISMOS GERAIS DE SINALIZAÇÃO
CELULAR
![Page 7: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/7.jpg)
![Page 8: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/8.jpg)
![Page 9: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/9.jpg)
Um pouco de Eletrofisiologia...
Luigi Galvani (1737 - 1798)
![Page 10: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/10.jpg)
Princípios da Eletrofisiologia
Células excitáveis:
- Células musculares
- Células nervosas
![Page 11: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/11.jpg)
A excitação celular
A excitação celular é desencadeada por um
processo denominado DESPOLARIZAÇÃO
CELULAR
Este processo inclui 4 etapas bem definidas:
- Estímulo
- Despolarização
- Repolarização
- Hiperpolarização
Relacionado com a CARGA
ELÉTRICA
![Page 12: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/12.jpg)
![Page 13: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/13.jpg)
Regrinhas Básicas
Despolarização EXCITAÇÃO Celular
Hiperpolarização INIBIÇÃO Celular
Entrada de íons POSITIVOS e/ou saída de íons NEGATIVOS
Despolarização
Entrada de íons NEGATIVOS e/ou saída de íons POSITIVOS
Hiperpolarização
![Page 14: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/14.jpg)
Aumento de carga POSITIVA no interior
da célula Despolarização
Aumento de carga NEGATIVA no interior
da célula Hiperpolarização
![Page 15: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/15.jpg)
ALVOS DE AÇÃO DOS FÁRMACOS
![Page 16: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/16.jpg)
PRINCIPAIS FUNÇÕES DAS PROTEÍNAS
Receptores
Canais iônicos
Transportadores
Enzimas
Proteínas estruturais
![Page 17: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/17.jpg)
Proteínas
São constituídas por aminoácidos
![Page 18: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/18.jpg)
Estrutura proteica
![Page 19: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/19.jpg)
SÍNTESE DE PROTEÍNAS
![Page 20: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/20.jpg)
TRANSCRIÇÃO
![Page 21: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/21.jpg)
TRADUÇÃO
![Page 22: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/22.jpg)
![Page 23: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/23.jpg)
![Page 24: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/24.jpg)
![Page 25: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/25.jpg)
![Page 26: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/26.jpg)
RECEPTORES
Agonistas
Antagonistas
![Page 27: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/27.jpg)
RECEPTORES
![Page 28: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/28.jpg)
TIPOS DE RECEPTORES
Ionotrópicos
Metabotrópicos
Catalíticos
Intracelulares
![Page 29: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/29.jpg)
Receptores Ionotrópicos
Neurotransmissores
![Page 30: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/30.jpg)
RECEPTORES IONOTRÓPICOS
Também chamados de canais iônicos dependentes
de ligante
![Page 31: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/31.jpg)
RECEPTORES IONOTRÓPICOS
![Page 32: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/32.jpg)
RECEPTORES IONOTRÓPICOS
![Page 33: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/33.jpg)
![Page 34: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/34.jpg)
CANAIS IÔNICOS
![Page 35: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/35.jpg)
CLASSIFICAÇÃO DOS CANAIS IÔNICOS
Dependentes de Ligantes
(ionotrópicos)
Dependentes de Voltagem
Dependentes de Metabólitos
![Page 36: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/36.jpg)
DEPENDENTES DE VOLTAGEM
![Page 37: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/37.jpg)
![Page 38: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/38.jpg)
Fármacos que atuam em Canais Iônicos
Dependentes de Voltagem
![Page 39: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/39.jpg)
DEPENDENTES DE METABÓLITOS
![Page 40: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/40.jpg)
Receptores Metabotrópicos
Neurotransmissores
Hormônios
Citocinas
![Page 41: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/41.jpg)
RECEPTORES METABOTRÓPICOS
São receptores inicialmente ligados ao metabolismo
São frequentemente chamados de receptores
acoplados a Proteína G (GPCR)
![Page 42: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/42.jpg)
RECEPTORES METABOTRÓPICOS
![Page 43: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/43.jpg)
RECEPTORES METABOTRÓPICOS
![Page 44: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/44.jpg)
RECEPTORES METABOTRÓPICOS
Soares, 2012
![Page 45: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/45.jpg)
![Page 46: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/46.jpg)
RECEPTORES METABOTRÓPICOS
![Page 47: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/47.jpg)
RECEPTORES METABOTRÓPICOS
![Page 48: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/48.jpg)
RECEPTORES METABOTRÓPICOS (AC)
![Page 49: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/49.jpg)
![Page 50: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/50.jpg)
![Page 51: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/51.jpg)
RECEPTORES METABOTRÓPICOS (AC)
![Page 52: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/52.jpg)
![Page 53: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/53.jpg)
RECEPTORES METABOTRÓPICOS (PLC)
![Page 54: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/54.jpg)
RECEPTORES METABOTRÓPICOS (PLC)
![Page 55: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/55.jpg)
GPCR E CANAIS IÔNICOS
![Page 56: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/56.jpg)
RECEPTORES METABOTRÓPICOS
Soares , 2012
![Page 57: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/57.jpg)
SINALIZAÇÃO POR ÓXIDO NÍTRICO (NO)
Molécula gasosa solúvel
Importante sinalizador celular
É sintetizado a partir do aminoácido L-arginina
A enzima que catalisa a formação do NO é a NOS
(óxido nítrico sintase), está presente
predominantemente em células endoteliais e
neurônios (eNOS e nNOS, respectivamente)
Tipos de NOS:
- cNOS (Constitutiva)
- iNOS (Induzida)
![Page 58: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/58.jpg)
SINALIZAÇÃO POR ÓXIDO NÍTRICO (NO)
![Page 59: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/59.jpg)
SINALIZAÇÃO POR ÓXIDO NÍTRICO (NO)
![Page 60: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/60.jpg)
SINALIZAÇÃO POR ÓXIDO NÍTRICO (NO)
![Page 61: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/61.jpg)
Receptores Catalíticos
Fatores de Crescimento
Citocinas
Fatores Tróficos
Hormônios
![Page 62: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/62.jpg)
RECEPTORES CATALÍTICOS
São proteínas transmembrana que possuem
atividade catalítica intrínseca
Possuem inúmeras funções celulares
Quando são ativados, desencadeiam uma cascata
de ativação de proteínas intracelulares por meio da
fosforilação de resíduos de tirosina (tirosina
quinases) ou serina/treonina (serina/treonina
quinases)
O que é FOSFORILAÇÃO????
![Page 63: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/63.jpg)
![Page 64: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/64.jpg)
RECEPTORES CATALÍTICOS
![Page 65: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/65.jpg)
RECEPTORES CATALÍTICOS
![Page 66: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/66.jpg)
RECEPTORES CATALÍTICOS
![Page 67: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/67.jpg)
RECEPTORES CATALÍTICOS
![Page 68: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/68.jpg)
Cross-Talking
![Page 69: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/69.jpg)
Cross-Talking
![Page 70: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/70.jpg)
Receptores Intracelulares
Hormônios
![Page 71: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/71.jpg)
RECEPTORES INTRACELULARES
São receptores localizados no interior das células
São ativados por substâncias LIPOFÍLICAS!
Atuam DIRETAMENTE no DNA da célula
Ativam fatores de transcrição genéticos
![Page 72: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/72.jpg)
RECEPTORES INTRACELULARES
![Page 73: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/73.jpg)
TRANSPORTADORES PASSIVOS
![Page 74: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/74.jpg)
TRANSPORTADORES ATIVOS (BOMBAS)
Omeprazol
![Page 75: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/75.jpg)
ENZIMAS
AINES
![Page 76: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/76.jpg)
PROTEÍNAS ESTRUTURAIS
![Page 77: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/77.jpg)
DNA
![Page 78: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/78.jpg)
RNA
Antibióticos
![Page 79: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/79.jpg)
Interação Fármaco-Receptor
![Page 80: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/80.jpg)
TIPOS DE INTERAÇÕES
Interação eletrostática
Interação dipolo-dipolo
Interação hidrofóbica
Pontes de Hidrogênio
Força de Van der Waals
Ligação iônica
Ligação covalente
![Page 81: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/81.jpg)
CONCENTRAÇÃO X EFEITO
![Page 82: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/82.jpg)
Ka = Constante de afinidade
Determina a POTÊNCIA
do fármaco
![Page 83: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/83.jpg)
POTÊNCIA X EFICÁCIA
![Page 84: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/84.jpg)
POTÊNCIA E EFICÁCIA
![Page 85: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/85.jpg)
CLASSIFICAÇÃO DAS DROGAS
![Page 86: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/86.jpg)
AGONISTAS TOTAIS
Produzem 100% do efeito análogo as substâncias endógenas
![Page 87: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/87.jpg)
AGONISTAS PARCIAIS
Não produzem 100% da resposta, mesmo ocupando
100% dos receptores
![Page 88: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/88.jpg)
AGONISTAS INVERSOS
Produzem efeito inverso do agonista
NÃO é um
antagonista!!!!!!
“Desativação”
![Page 89: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/89.jpg)
![Page 90: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/90.jpg)
ANTAGONISTAS
Bloqueiam a ação dos agonistas
NÃO POSSUEM ATIVIDADE INTRÍNSECA
Se ligam aos receptores BLOQUEANDO seu sítio
de ligação
![Page 91: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/91.jpg)
ANTAGONISTAS
![Page 92: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/92.jpg)
![Page 93: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/93.jpg)
![Page 94: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/94.jpg)
![Page 95: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/95.jpg)
![Page 96: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/96.jpg)
DESSENSIBILIZAÇÃO OU TAQUIFILAXIA
![Page 97: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/97.jpg)
![Page 98: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/98.jpg)
![Page 99: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/99.jpg)
![Page 100: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/100.jpg)
![Page 101: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/101.jpg)
![Page 102: Farmacodinâmica](https://reader033.fdocumentos.com/reader033/viewer/2022060202/559c51781a28abd7458b47de/html5/thumbnails/102.jpg)
Antibióticos e Antineoplásicos