Incretinas, Adipocinas,

Obesidade e

Resistência à Insulina

Incretinas(INtestinal seCRETion

of Insulin)

Tecido Adiposo

e

Adipocitocinas

Leptina

Leptina

ESTABILIZA O PESO

SACIEDADEANOREXÍGENA

AUMENTA GASTO

ENERGÉTICO

Ghrelina

GANHO DE PESO

ADIPOGÊNICAOREXÍGENA

ANTILIPOLÍTICAREDUZ GASTO

ENERGÉTICO

Adiponectina

Figure 1. The various ADIPONECTIN species affect liver hepatocytes and skeletal

muscle myocytes differently. Only the high molecular weight (HMW) multimer and the

hexamer forms of Adiponectin act on hepatocytes via AMP-activated protein kinase

(AMPK) to inhibit glucose production and reduce intracellular triglycerides (TGs) and

insulin resistance. By contrast, the Cys39Ser mutant trimer and globular domain

mutants, as well as all wild-type Adiponectin species, act on myocytes via AMPK to

stimulate glucose uptake and reduce intracellular TGs and insulin resistance. Note: figure

adapted from Waki, H. et al. (2003) J. Biol. Chem. 278:40352.]

Obesidade e

Resistência à

Insulina