Em Brio Genesis Sp

7/25/2019 Em Brio Genesis Sp

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EMBRIOGENESIS

Rita RositaLaboratorium Anatomi-Histologi



TUJUAN :

• Taa!an !"r#"mbangan "mbr$o• Gangguan !"r#"mbangan"mbrio

%O&O& BAHASAN :• Gam"tog"n"sis

• Trans!ort gam"t 'an ("rtilisasi

• %"mb"laan s"l 'an im!lantasi• )i("r"nsiasi 'an maturasi *aringan



Gam"tog"n"sis

T"r'iri 'ari + (as" :

, %"mb"ntu#an %G.s 'an migrasim"nu*u gona'

/ %"ning#atan *umla s"l

0 %"ngurangan *umla #romosom

+ Maturasi stru#tur 'an (ungsio1um 'an s!"rma



TRANS%ORT GAMET )AN2ERTILISASI

• O1ulasi trans!ort o1um : 3 %"rt"ngaan si#lus m"nstruasi

3 %"ngaru LH m"iosis I s"l"sai

m"iosis II s! m"ta(as" 0 *am sblmo1ulasi

3 2imbria" m"li!uti o1arium4 tuba

#ontra#si ritmis4 g"ra#an 5ilia !a'a"!it"l mu#osa



Trans!ort s!"rma :

• 6 : maturasi stru#tur 'an (ungsiTubulus s"mini("rus : s!"rma matur t!nonmotil s"5!asi( m"nu*u 5a!ut"!i'i'$mis 7aliran 5airan4 #ontra#si otot

!olos4 g"ra#an 5ilia8 ,/ r maturasibio#imia 7m"ngi#at gli#o!rot"in8 5au'a"!i'i'$mis #a!ab"l untu#("rtilisasi"*a#ulasi 'u5tus'"(("r"nsmi9"' 'gn 5airan asils"#r"si 1"si5ula s"minalis 'an glan'ula!rostat "*a#ulat : /- ml4 +;-/<; *uta

s!"rma

TRANS%ORT GAMET )AN 2ERTILISASI



• = : m"n5a!ai am!ula tuba

1agina 5analis 5"r1i5alis 5a1um ut"ri tuba ut"rina

• 2"rtilisasi 'a!at t"r*a'i bila t"r*a'i :

3 .a!asitasi :%"l"!asan gli#o!rot"in

3 R"a#si a#rosom :

T"r*a'i s"t"la s!"rma b"ri#atan'"ngan >ona !"llu5i'a4 '"nganm"ngasil#an "n>im a5rosin 'antri!sin

Trans!ort s!"rma :



2ERTILISASI

• 2usi gam"t = 'an 6 'i am!ula tuba• T"rbagi 0 (as" :

, %"n"trasi 5orona ra'iata

/ %"n"trasi >ona !"llu5i'a0 2usi m"mbran s"l oo5$t" 'an s!"rma

• R"s!on oo5$t" : 3 .orti5al an' >ona r"a5tion

3 M"n$"l"sai#an m"iosis II oo5$t" ? !olarbo'$ II

3 A#ti1asi m"tabolism" oo5$t"

TRANS%ORT GAMET )AN 2ERTILISASI



%EMBELAHAN SEL )AN IM%LANTASI

• @$got" /5"ll stag"mitosis blastom"r" 5"ll stag"5om!a5tionmorula

• %"mb"ntu#an blasto5$st 3 T"r*a'i saat morula m"masu#i 5a1um

ut"ri

3 %"n"trasi 5airan m"lalui >ona !"llu5i'a

3 T"rb"ntu# 5a1itasblasto5o"l" blasto5$st

3 Inn"r 5"ll mass : "mbr$oblast

3 Out"r 5"ll mass : tro!oblast



Im!lantasi :

• &onta# I blasto5$st 1s mu#osa ut"rus7 (as" s"#r"tori8

• T"rbagi 0 (as" : 3 %"rsia!an ut"rus

3 A'"si utrus tro!oblast

3 Masu#n$a blasto5$st #" 'in'ig ut"rus

• )i 'in'ing ant"riorC!ost"rior 5or!us ut"ri

• %ros"s: ilangn$a >ona !"llu5i'a !olartro!oblast m"n$"ntu "n'om"trium

s"#r"si !rot"as" "n'om"triumm"n5air "mbrio masu# #" 'alam"n'om"trium



%EMBENTU&AN MULTI%LE .ELL LADER

• Bilaminar G"rm )is5 : 3 E!iblast

3 H$!oblast

•Trilaminar G"rm )is5

Gastrulasi 3 En'o'"rm

3 M"so'"rm 7 !' mgg #"-08

3 E#to'"rm

%"n"ntuan 5ranial 5au'al 'ari g"rm 'is5 bu55o!ar$ng"al m"mbran 'an5loa5al m"mbran



Organog"n"sis 7 + mgg8

• )i("r"nsiasi s"l stru#tur 'an

(ungsi s!"si(i#

in'u#si s"l lain• E#to'"rm : r #" ,-,

• M"so'"rm : r #"-,F

• En'o'"rm : ari #"-/,



)I2ERENSIASI JARINGAN2UNGSIONAL

• %"rio'" ("tal mgg #" lair

• In'i#ator tumbu #"mbang : .RL5ron-rum! l"ngt4 5m

• Usia ("tus : #ombinasi 'ata a#tuH%HT4 !an*ang4 b"rat4 'an#ara#t"risti# mor(ologi

• %"rubaan 'alam tia! bulan• a#tu #"lairan :

3 /; ariC+; mgg H%HT

3 / rC0 mgg s"t"la ("rtilisasi



T" uran on Human Embr$oni5)"1"lo!m"nt

• S /0:,/ )an s"sunggun$a &ami t"lam"n5i!ta#an manusia 'ari suatu sari!ati 7b"rasal8 'aritana

• S /0:,/ &"mu'ian &ami *a'i#an sari!ati ituNutfah 7$ang 'isim!an8 'alam t"m!at $ang #o#o7raim8

• S /0:,+ &"mu'ian Nutfah itu &ami *a'i#an Alaqoh4 lalu Alaqoh itu &ami *a'i#an Mudghoh4 'anMudghoh itu &ami *a'i#an tulang b"lulang4 lalu tulangb"lulang itu &ami bung#us '"ngan 'aging &"mu'ian&ami *a'i#an 'ia ma#lu# $ang 7b"rb"ntu#8 lain Ma#aMaa su5ila Alla4 %"n5i!ta Dang %aling Bai#



&ELAINAN &ONGENITAL

T$!" abnormalitas :

, Mal(ormation

/ )isru!tion0 )"(ormation

+ )$s!lasia

S$n'rom" : #"lom!o# #"lainanCanomali'"ngan !"n$"bab $ang sama



%"n$"bab &"lainan &ong"nital

, 2a#tor G"n"ti# :, Singl" g"n" 'isor'"r

/ .romosom" 'isor'"r

0 Multi(a#torial

/ 2a#tor Ling#ungan, In("#si mat"rnal

/ ."mi5al t"ratog"n0 2a#tor (isi#

+ 2a#tor mat"rnal

< 2a#tor m"#ani#



%r"natal )iagnosis

, In1asi1"

, Amnio5"nt"sis

/ .orioni5 1illi sam!ling

/ Non-in1asi1"

, USG

/ Mat"rnal s"rum s5r""ning



2"tal T"ra!$

• 2"tal trans(usion

• 2"tal m"'i5al tr"atm"nt

• 2"tal surg"r$

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